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1 John 4:3

And every spirit that dissolveth Jesus, is not of God: and this is Antichrist, of whom you have heard that he cometh, and he is now already in the world.

Challoner: That dissolveth JesusViz., either by denying his humanity, or his divinity.
Challoner: He is now already in the worldNot in his person, but in his spirit, and in his precursors.
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The verse in its languages

Vulgate (Clementine)
et omnis spiritus qui solvit Jesum, ex Deo non est, et hic est antichristus, de quo audistis quoniam venit, et nunc jam in mundo est.
Greek New Testament (SBLGNT)
καὶ πᾶν πνεῦμα ὃ μὴ ὁμολογεῖ τὸν Ἰησοῦν ἐκ τοῦ θεοῦ οὐκ ἔστιν· καὶ τοῦτό ἐστιν τὸ τοῦ ἀντιχρίστου, ὃ ἀκηκόατε ὅτι ἔρχεται, καὶ νῦν ἐν τῷ κόσμῳ ἐστὶν ἤδη.

Haydock's commentary

That dissolveth Jesus, viz. either by denying his humanity or his divinity. (Challoner)

This is antichrist;2 i.e. such is the spirit of antichrist, of whom you have heard that he cometh, or is to come in the latter times.

And he is now already in the world, not the chief and great antichrist, but his precursors, in whom he may be said to come. (Witham)

And he is now already in the world. Not in his person, but in his spirit and in his precursors. (Challoner)

2 Et hic est antichristus, kai touto (pneuma) to tou antichristou. By the Greek hic cannot agree with the man, and so the construction in Latin must be, hic est ille spiritus antichristi.

From Haydock's Catholic Bible Commentary, 1859, in the transcription made by Todd Easton and kept online by John Paul Wohlschied at johnblood.gitlab.io/haydock.

The Fathers on this verse

St Polycarp Epistle to the Philippians, Chapter VII. Avoid the Docetæ, and

“For whosoever does not confess that Jesus Christ has come in the flesh, is antichrist;” and whosoever does not confess the testimony of the cross, is of the devil; and whosoever perverts the oracles of the Lord to his own lusts, and says that there is neither a resurrection nor a judgment, he is the first-born of Satan. Wherefore, forsaking the vanity of many, and their false doctrines, let us return to the word which has been handed down to us from the beginning; “watching unto prayer,” and persevering in fasting; beseeching in our supplications the all-seeing God “not to lead us into temptation,” as the Lord has said: “The spirit truly is willing, but the flesh is weak.”

Tertullian The Prescription Against Heretics, Present Heresies (Seedlings of the Tares Noted by the Sacred Writers) Already Condemned in Scripture. This Descent of Later Heresy from the Earlier Traced in Several Instances

Besides all this, I add a review of the doctrines themselves, which, existing as they did in the days of the apostles, were both exposed and denounced by the said apostles. For by this method they will be more easily reprobated, when they are detected to have been even then in existence, or at any rate to have been seedlings of the (tares) which then were. Paul, in his first epistle to the Corinthians, sets his mark on certain who denied and doubted the resurrection. This opinion was the especial property of the Sadducees. A part of it, however, is maintained by Marcion and Apelles and Valentinus, and all other impugners of the resurrection. Writing also to the Galatians, he inveighs against such men as observed and defend circumcision and the (Mosaic) law. Thus runs Hebion’s heresy. Such also as “forbid to marry” he reproaches in his instructions to Timothy. …

Tertullian The Five Books Against Marcion, The Second Epistle to the Thessalonians. An Absurd Erasure of Marcion; Its Object Transparent. The Final Judgment on the Heathen as Well as the Jews Could Not Be Administered by Marcion's Christ. The Man of Sin--What? Inconsistency of Marcion's View. The Antichrist. The Great Events of the Last Apostasy Within the Providence and Intention of the Creator, Whose are All Things from the Beginning. Similarity of the Pauline Precepts with Those of the Creator

We are obliged from time to time to recur to certain topics in order to affirm truths which are connected with them. We repeat then here, that as the Lord is by the apostle proclaimed as the awarder of both weal and woe, He must be either the Creator, or (as Marcion would be loth to admit) One like the Creator, “with whom it is a righteous thing to recompense tribulation to them who afflict us, and to ourselves, who are afflicted, rest, when the Lord Jesus shall be revealed as coming from heaven with the angels of His might and in flaming fire.” The heretic, however, has erased the flaming fire , no doubt that he might extinguish all traces herein of our own God. But the folly of the obliteration is clearly seen. …

Tertullian On the Flesh of Christ, Divine Strictures on Various Heretics Descried in Various Passages of Prophetical Scripture. Those Who Assail the True Doctrine of the One Lord Jesus Christ, Both God and Man, Thus Condemned

For when Isaiah hurls denunciation against our very heretics, especially in his “Woe to them that call evil good, and put darkness for light,” he of course sets his mark upon those amongst you who preserve not in the words they employ the light of their true significance, (by taking care) that the soul should mean only that which is so called, and the flesh simply that which is confest to our view, and God none other than the One who is preached. Having thus Marcion in his prophetic view, he says, “I am God, and there is none else; there is no God beside me.” And when in another passage he says, in like manner, “Before me there was no God,” he strikes at those inexplicable genealogies of the Valentinian Æons. …

Tertullian On the Resurrection of the Flesh, The Scriptures Forbid Our Supposing Either that the Resurrection is Already Past, or that It Takes Place Immediately at Death. Our Hopes and Prayers Point to the Last Great Day as the Period of Its Accomplishment

We must after all this turn our attention to those scriptures also which forbid our belief in such a resurrection as is held by your Animalists (for I will not call them Spiritualists ), that it is either to be assumed as taking place now, as soon as men come to the knowledge of the truth, or else that it is accomplished immediately after their departure from this life. Now, forasmuch as the seasons of our entire hope have been fixed in the Holy Scripture, and since we are not permitted to place the accomplishment thereof, as I apprehend, previous to Christ’s coming, our prayers are directed towards the end of this world, to the passing away thereof at the great day of the Lord, of His wrath and vengeance, the last day, which is hidden (from all), and known to none but the Father, although announced beforehand by signs and wonders, and the dissolution of the elements, and the conflicts o …

Tertullian Against Praxeas, Christ Not the Father, as Praxeas Said. The Inconsistency of This Opinion, No Less Than Its Absurdity, Exposed. The True Doctrine of Jesus Christ According to St. Paul, Who Agrees with Other Sacred Writers

And so, most foolish heretic, you make Christ to be the Father, without once considering the actual force of this name, if indeed Christ is a name, and not rather a surname, or designation; for it signifies “Anointed.” But Anointed is no more a proper name than Clothed or Shod; it is only an accessory to a name. Suppose now that by some means Jesus were also called Vestitus ( Clothed ), as He is actually called Christ from the mystery of His anointing, would you in like manner say that Jesus was the Son of God, and at the same time suppose that Vestitus was the Father? Now then, concerning Christ, if Christ is the Father, the Father is an Anointed One, and receives the unction of course from another. Else if it is from Himself that He re ceives it, then you must prove it to us. …

St Cyprian The Epistles of Cyprian, Epistle LXXII

15. But if we consider what the apostles thought about heretics, we shall find that they, in all their epistles, execrated and detested the sacrilegious wickedness of heretics. For when they say that “their word creeps as a canker,” how is such a word as that able to give remission of sins, which creeps like a canker to the ears of the hearers? And when they say that there can be no fellowship between righteousness and unrighteousness, no communion between light and darkness, how can either darkness illuminate, or unrighteousness justify? And when they say that “they are not of God, but are of the spirit of Antichrist,” how can they transact spiritual and divine matters, who are the enemies of God, and whose hearts the spirit of Antichrist has possessed? Wherefore, if, laying aside the errors of human dispute, we return with a sincere and religious faith to the evangelical authority and …

St Cyprian Three Books of Testimonies Against the Jews, That although from the beginning He had been the Son of God, yet He had to be begotten again according to the flesh

In the second Psalm: “The Lord said unto me, Thou art my Son; this day have I begotten Thee. Ask of me, and I will give Thee the nations for Thine inheritance, and the bounds of the earth for Thy possession.” Also in the Gospel according to Luke: “And it came to pass, when Elisabeth heard the salutation of Mary, the babe leaped in her womb; and she was filled with the Holy Ghost, and she cried out with a loud voice, and said, Blessed art thou among women, and blessed is the fruit of thy womb. And whence does this happen to me, that the mother of my Lord should come to me?” Also Paul to the Galatians: “But when the fulness of the time was come, God sent His Son, born of a woman.” Also in the Epistle of John: “Every spirit which confesses that Jesus Christ is come in the flesh is of God. But whosoever denies that He is come in the flesh is not of God, but is of the spirit of Antichrist.”

St Augustine Reply to Faustus the Manichæan, Faustus claims that the Manichæans and not the Catholics are consistent believers in the Gospel, and seeks to establish this claim by comparing Manichæan and Catholic obedience to the precepts of the Gospel. Augustin exposes the hypocrisy of the Manichæans and praises the asceticism of Catholics

4. Augustin replied: I have already said that the Lord Jesus Christ repeatedly calls Himself the Son of man, and that the Manichæans have contrived a silly story about some fabulous First Man, who figures in their impious heresy, not earthly, but combined with spurious elements, in opposition to the apostle, who says, "The first man is of the earth, earthy;" and that the apostle carefully warns us, "If any one preaches to you differently from what we have preached, let him be accursed." So that we must believe Christ to be the Son of man according to apostolic truth, not according to Manichæan error. …

St Augustine Ten Homilies on the First Epistle of John, 1 John III. 19, IV. 3

12. There remains then the test by which it is to be proved to be the Spirit of God. He has indeed set down a sign, and this, belike, difficult: let us see, however. We are to recur to that charity; it is that which teacheth us, because it is the unction. However, what saith he here? “Prove the spirits, whether they be from God: because many false prophets have gone out into this world.” Now there are all heretics and all schismatics. How then am I to prove the spirit? He goes on: “In this is known the Spirit of God.” Wake up the ears of your heart. We were at a loss; we were saying, Who knows? who discerns? Behold, he is about to tell the sign. …

St Augustine Ten Homilies on the First Epistle of John, 1 John V. 1-3

7. “For this is the love of God, that we keep His commandments.” Already ye have heard, “On these two commandments hang all the law and the prophets.” See how He would not have thee divide thyself over a multitude of pages: “On these two commandments hang all the law and the prophets.” On what two commandments? “Thou shalt love the Lord thy God with all thy heart, and with all thy soul, and with all thy mind. And, thou shalt love thy neighbor as thyself. On these two commandments hang all the law and the prophets.” See here of what commandments this whole epis tle talks. Therefore hold fast love, and set your minds at rest. Why fearest thou lest thou do evil to some man? Who does evil to the man he loves? Love thou: it is impossible to do this without doing good. But it may be, thou rebukest? Kindness does it, not fierceness. …

Theodoret Dialogues. The “Eranistes” or “Polymorphus” of the Blessed Theodoretus, Bishop of Cyrus, The Immutable

Orth. What was taken of him was not man’s likeness, but man’s nature. For “form of a servant” is understood just as “the form of God” is understood to mean God’s nature. He took this, and so was made in the likeness of man, and was found in fashion as a man. For, being God, He seemed to be man, on account of the nature which He took. The evangelist, however, speaks of His being made in the likeness of man as His being made flesh. But that you may know that they who deny the flesh of the Saviour are of the opposite spirit, hear the great John in his Catholic Epistle saying “Every spirit that confesses that Jesus Christ is come in the flesh is of God, and every spirit that confesses not that Jesus Christ is come in the flesh is not of God, and this is that spirit of Anti-Christ.”

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The Catechism cites this verse