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1 Timothy 2:5

For there is one God, and one mediator of God and men, the man Christ Jesus:

Challoner: One mediatorChrist is the one and only mediator of redemption, who gave himself, as the apostle writes in the following verse.
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The verse in its languages

Vulgate (Clementine)
Unus enim Deus, unus et mediator Dei et hominum homo Christus Jesus :
Greek New Testament (SBLGNT)
εἷς γὰρ θεός, εἷς καὶ μεσίτης θεοῦ καὶ ἀνθρώπων ἄνθρωπος Χριστὸς Ἰησοῦς,

Haydock's commentary

On verses 5 to 6

One mediator of God and men, the man Christ Jesus: who gave himself a redemption for all. Take all these words together, and we may easily understand in what sense the apostle calls our Saviour Christ, the one or only mediator; that is, he is the only mediator, who at the same time is our Redeemer; the only mediator who could mediate betwixt God, the person offended by sin, and men the offenders; the only mediator who reconciled God to mankind by his incarnation and death, by the infinite price of his blood, by his own merits, independently of the merits of any other. All Catholics allow that the dignity and office of mediator in this sense belongs only to our Redeemer, Jesus Christ, the Son of God, made man to save us. The sense then of this place is, that as there is but one God, who created all, so there is but one mediator, who redeemed all. But yet the name of mediator is not so appropriated to Christ, but that in an inferior and different sense the Angels and saints in heaven, and even men on earth, who pray to God for the salvation of others, may be called mediators, intercessors, or advocates; and we may apply ourselves to them to pray, intercede, and mediate for us, without any injury to Christ, since we acknowledge that all their intercession and mediation is always grounded on the merits of Christ, our Redeemer. The same word for mediator, in the Greek as well as in the Latin, is given to Moses, God's servant. (Galatians iii. 19.) See also Deuteronomy v. 5. The words of our Saviour himself, (Matthew xxiii.) taken according to the letter, contain an express prohibition of being called masters, or fathers; and this reason is given, because all men have one Father in heaven, and because Christians have one master, Christ. Yet no one can justly pretend from thence, that in a different sense, a man may not be called father or master, without any injury to God, or to Christ. (Witham)

Read on

Christ is the one and only mediator of redemption; who gave himself, as the apostle writes, a redemption for all. He is also the only mediator, who stands in need of no other to recommend his petitions to the Father. But this is not against our seeking the prayers and intercessions, as well of the faithful upon earth, as of the saints and Angels in heaven, for obtaining mercy, grace, and salvation, through Jesus Christ. As St. Paul himself often desired the help of the prayers of the faithful, without any injury to the mediatorship of Jesus Christ. (Challoner)

If there be other mediators among the Angels and saints, they are only so in subordination to the first[Christ], who by themselves have no right to mediation or favours, and who cannot demand them but through the merits of him[Christ] who is our only essential mediator. (Estius, Menochius, &c.) Consult Judges iii. 9; 2 Esdras ix. 17; Acts vii. 35.

A redemption for all. Not only for the predestinated, not only for the just, not only for the faithful, but for all Gentiles and infidels: and therefore he says again, (chap. iv. 10.) that Christ is the Saviour of all men, and especially of the faithful. See St. Augustine1 and St. Chrysostom.2 (Witham)

From Haydock's Catholic Bible Commentary, 1859, in the transcription made by Todd Easton and kept online by John Paul Wohlschied at johnblood.gitlab.io/haydock.

The Fathers on this verse

Pseudo-Ignatius Epistle to the Tarsians, Chapter IV. Continuation

And [know ye, moreover], that He who was born of a woman was the Son of God, and He that was crucified was “the first-born of every creature,” and God the Word, who also created all things. For says the apostle, “There is one God, the Father, of whom are all things; and one Lord Jesus Christ, by whom are all things.” And again, “For there is one God, and one Mediator between God and man, the man Christ Jesus;” and, “By Him were all things created that are in heaven, and on earth, visible and invisible; and He is before all things, and by Him all things consist.”

Pseudo-Ignatius Epistle to the Antiochians, Chapter IV. Continuation

The Evangelists, too, when they declared that the one Father was “the only true God,” did not omit what concerned our Lord, but wrote: “In the beginning was the Word, and the Word was with God, and the Word was God. The same was in the beginning with God. All things were made by Him, and without Him was not anything made that was made.” And concerning the incarnation: “The Word,” says [the Scripture], “became flesh, and dwelt among us.” And again: “The book of the generation of Jesus Christ, the son of David, the son of Abraham.” And those very apostles, who said “that there is one God,” said also that “there is one Mediator between God and men.” Nor were they ashamed of the incarnation and the passion. For what says [one]? “The man Christ Jesus, who gave Himself” for the life and salvation of the world.

St Irenaeus Against Heresies: Book V, Chapter XVII. There is but one Lord

1. Now this being is the Creator ( Demiurgus ), who is, in respect of His love, the Father; but in respect of His power, He is Lord; and in respect of His wisdom, our Maker and Fashioner; by transgressing whose commandment we became His enemies. And therefore in the last times the Lord has restored us into friendship through His incarnation, having become “the Mediator between God and men;” propitiating indeed for us the Father against whom we had sinned, and cancelling ( consolatus ) our disobedience by His own obedience; conferring also upon us the gift of communion with, and subjection to, our Maker. For this reason also He has taught us to say in prayer, “And forgive us our debts;” since indeed He is our Father, whose debtors we were, having transgressed His commandments. …

Tertullian On the Flesh of Christ, The Valentinian Figment of Christ's Flesh Being of a Spiritual Nature, Examined and Refuted Out of Scripture

Valentinus, indeed, on the strength of his heretical system, might consistently devise a spiritual flesh for Christ. Any one who refused to believe that that flesh was human might pretend it to be anything he liked, forasmuch as (and this remark is applicable to all heretics ), if it was not human, and was not born of man, I do not see of what substance Christ Himself spoke when He called Himself man and the Son of man, saying : “But now ye seek to kill me, a man that hath told you the truth;” and “The Son of man is Lord of the Sabbath-day.” For it is of Him that Isaiah writes: “A man of suffering, and acquainted with the bearing of weakness;” and Jeremiah: “He is a man, and who hath known Him?” and Daniel: “Upon the clouds (He came) as the Son of man.” The Apostle Paul likewise says: “The man Christ Jesus is the one Mediator between God and man.” Also Peter, in the Acts of the Apostles, …

Tertullian On the Resurrection of the Flesh, Conclusion. The Resurrection of the Flesh in Its Absolute Identity and Perfection. Belief of This Had Become Weak. Hopes for Its Refreshing Restoration Under the Influences of the Paraclete

And so the flesh shall rise again, wholly in every man, in its own identity, in its absolute integrity. Wherever it may be, it is in safe keeping in God’s presence, through that most faithful “Mediator between God and man, (the man) Jesus Christ,” who shall reconcile both God to man, and man to God; the spirit to the flesh, and the flesh to the spirit. Both natures has He already united in His own self; He has fitted them together as bride and bridegroom in the reciprocal bond of wedded life. Now, if any should insist on making the soul the bride, then the flesh will follow the soul as her dowry. The soul shall never be an outcast, to be had home by the bridegroom bare and naked. She has her dower, her outfit, her fortune in the flesh, which shall accompany her with the love and fidelity of a foster-sister. …

Tertullian Against Praxeas, The Distinction of the Father and the Son, Thus Established, He Now Proves the Distinction of the Two Natures, Which Were, Without Confusion, United in the Person of the Son. The Subterfuges of Praxeas Thus Exposed

But why should I linger over matters which are so evident, when I ought to be attacking points on which they seek to obscure the plainest proof? For, confuted on all sides on the distinction between the Father and the Son, which we maintain without destroying their inseparable union, as (by the examples) of the sun and the ray, and the fountain and the river, yet, by help of (their conceit) an indivisible number, (with issues) of two and three, they endeavour to interpret this distinction in a way which shall nevertheless tally with their own opinions: so that, all in one Person, they distinguish two, Father and Son, understanding the Son to be flesh, that is man, that is Jesus; and the Father to be spirit, that is God, that is Christ. Thus they, while contending that the Father and the Son are one and the same, do in fact begin by dividing them rather than uniting them. …

St Hippolytus On Numbers

Now, in order that He might be shown to have together in Himself at once the nature of God and that of man, as the apostle, too, says: “Mediator between God and men, the man Christ Jesus. Now a mediator is not of one man, but two,”, it was therefore necessary that Christ, in becoming the Mediator between God and men, should receive from both an earnest of some kind, that He might appear as the Mediator between two distinct persons.

Novatian A Treatise of Novatian Concerning the Trinity, Chapter XXI

And indeed I could set forth the treatment of this subject by all heavenly Scriptures, and set in motion, so to speak, a perfect forest of texts concerning that manifestation of the divinity of Christ, except that I have not so much undertaken to speak against this special form of heresy, as to expound the rule of truth concerning the person of Christ. Although, however, I must hasten to other matters, I do not think that I must pass over this point, that in the Gospel the Lord declared, by way of signifying His majesty, saying, “Destroy this temple, and in three days I will build it up again.” Or when, in another passage, and on another subject, He declares, “I have power to lay down my life, and again to take it up; for this commandment I have received of my Father.” Now who is it who says that He can lay down His life, or can Himself recover His life again, because He has received it …

St Augustine Book VII, Chapter XVIII

24. And I sought a way of acquiring strength sufficient to enjoy Thee; but I found it not until I embraced that “Mediator between God and man, the man Christ Jesus,” “who is over all, God blessed for ever,” calling unto me, and saying, “I am the way, the truth, and the life,” and mingling that food which I was unable to receive with our flesh. For “the Word was made flesh,” that Thy wisdom, by which Thou createdst all things, might provide milk for our infancy. For I did not grasp my Lord Jesus, I, though humbled, grasped not the humble One; nor did I know what lesson that infirmity of His would teach us. …

St Augustine Book X, Chapter XLIII

68. But the true Mediator, whom in Thy secret mercy Thou hast pointed out to the humble, and didst send, that by His example also they might learn the same humility, that “Mediator between God and men, the man Christ Jesus,” appeared between mortal sinners and the immortal Just One, mortal with men, just with God; that because the reward of righteousness is life and peace, He might, by righteousness conjoined with God, cancel the death of justified sinners, which He willed to have in common with them. Hence He was pointed out to holy men of old; to the intent that they, through faith in His Passion to come, even as we through faith in that which is past, might be saved. For as man He was Mediator; but as the Word He was not between, because equal to God, and God with God, and together with the Holy Spirit one God.

St Augustine Book XI, Chapter XXIX

39. But “because Thy loving-kindness is better than life,” behold, my life is but a distraction, and Thy right hand upheld me in my Lord, the Son of man, the Mediator between Thee, The One, and us the many, in many distractions amid many things, that through Him I may apprehend in whom I have been apprehended, and may be recollected from my old days, following The One, forgetting the things that are past; and not distracted, but drawn on, not to those things which shall be and shall pass away, but to those things which are before, not distractedly, but intently, I follow on for the prize of my heavenly calling, where I may hear the voice of Thy praise, and contemplate Thy delights, neither coming nor passing away. But now are my years spent in mourning. And Thou, O Lord, art my comfort, my Father everlasting. …

St Augustine Letter CXXXVII

12. Wherefore the Word of God, who is also the Son of God, co-eternal with the Father, the Power and the Wisdom of God, mightily pervading and harmoniously ordering all things, from the highest limit of the intelligent to the lowest limit of the material creation, revealed and concealed, nowhere confined, nowhere divided, nowhere distended, but without dimensions, everywhere present in His entirety, this Word of God, I say, took to Himself, in a manner entirely different from that in which He is present to other creatures, the soul and body of a man, and made, by the union of Himself therewith, the one person Jesus Christ, Mediator between God and men, in His Deity equal with the Father, in His flesh, i.e. …

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The Catechism cites this verse