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2 Corinthians 5:16

Wherefore henceforth, we know no man according to the flesh. And if we have known Christ according to the flesh; but now we know him so no longer.

Challoner: We know no man according to the fleshThat is, we consider not any man with regard to his nation, family, kindred, or other natural qualities or advantages; but only with relation to Christ, and according to the order of divine charity, in God, and for God. The apostle adds, that even with respect to Christ himself, he now no longer considers him according to the flesh, by taking a satisfaction in his being his countryman; his affection being now purified from all such earthly considerations.
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The verse in its languages

Vulgate (Clementine)
Itaque nos ex hoc neminem novimus secundum carnem. Et si cognovimus secundum carnem Christum, sed nunc jam non novimus.
Greek New Testament (SBLGNT)
Ὥστε ἡμεῖς ἀπὸ τοῦ νῦν οὐδένα οἴδαμεν κατὰ σάρκα· εἰ καὶ ἐγνώκαμεν κατὰ σάρκα Χριστόν, ἀλλὰ νῦν οὐκέτι γινώσκομεν.

Haydock's commentary

Wherefore, henceforth we know no man according to the flesh; i.e. having our thoughts and hearts fixed upon Christ, as he is risen, and has prepared for us an immortal life, we know not, i.e. we do not esteem any thing in this mortal life, nor any man according to any human considerations of this life; we regard not whether they are Jews, and the sons of Abraham, or Gentiles; nay, if we have known and esteemed Christ, as descending from Abraham and David, now we know him so no longer, nor consider him as born a mortal man, but as he is risen immortal, and will bless us with an immortal and eternal glory. (Witham)

From Haydock's Catholic Bible Commentary, 1859, in the transcription made by Todd Easton and kept online by John Paul Wohlschied at johnblood.gitlab.io/haydock.

The Fathers on this verse

Clement of Alexandria The Stromata, or Miscellanies, Book III

Quoniam autem qui introducunt indifferentiam, paucas quasdam Scripturas detorquentes, titillanti suæ voluptati eas suffragari existimant; rum præcipue illam quoque: “Peccatum enim vestri non dominabitur; non estis enim sub lege, sed sub gratia;” et aliquas alias hujusmodi, quarum posthæc non est rationi consentaneum ut faciam mentionem (non enim nayera instruo piraticam), age paucis eorum argumentum perfringamus. Ipse enim egregius Apostolus in verbis, quæ prædictæ dictioni subjungit, intentati criminis afferet solutionem: “Quid ergo? peccabimus, quiâ non sumus sub lege, sed sub gratia? Absit.” Adeo divine et prophetice e vestigio dissolvit artem voluptatis sophisticam. Non intelligunt ergo, ut videtur, quod “omnes nos oportet manifestari ante tribunal Christi, ut referat unusquisque per corpus ea quæ fecit, sire bonum, sive malum:” ut quæ per corpus fecit aliquis, recipiat. …

Clement of Alexandria The Stromata, or Miscellanies, Fragments of Clemens Alexandrinus

On 2 Cor. v. 16 . “And if we have known Christ after the flesh.”

Origen Origen De Principiis, Chapter VI

7. I think, indeed, that Jeremiah the prophet, also, understanding what was the nature of the wisdom of God in him, which was the same also which he had assumed for the salvation of the world, said, “The breath of our countenance is Christ the Lord, to whom we said, that under His shadow we shall live among the nations.” And inasmuch as the shadow of our body is inseparable from the body, and unavoidably performs and repeats its movements and gestures, I think that he, wishing to point out the work of Christ’s soul, and the movements inseparably belonging to it, and which accomplished everything according to His movements and will, called this the shadow of Christ the Lord, under which shadow we were to live among the nations. For in the mystery of this assumption the nations live, who, imitating it through faith, come to salvation. …

Origen Origen Against Celsus, Chapter XXXIX

Now let us hear what it is that he invites us to learn, that we may ascertain from him how we are to know God, although he thinks that his words are beyond the capacity of all Christians. “Let them hear,” says he, “if they are able to do so.” We have then to consider what the philosopher wishes us to hear from him. But instead of instructing us as he ought, he abuses us; and while he should have shown his goodwill to those whom he addresses at the outset of his discourse, he stigmatizes as “a cowardly race” men who would rather die than abjure Christianity even by a word, and who are ready to suffer every form of torture, or any kind of death. …

Origen Origen's Commentary on Matthew, Chapter XVII

Now bring together from the Gospels those who call Him Son of David, as she, and the blind men in Jericho; and who call Him Son of God, and that without the addition “truly” like the demoniacs who say, “What have we to do with Thee, Thou Son of God;” and who call Him so with the addition “truly,” like those in the boat who worshipped Him saying, “Truly Thou art the Son of God.” For the bringing together of these passages will, I think, be useful to you with a view to seeing the difference of those who come (to Jesus); some indeed come as to Him “who was born of the seed of David according to the flesh;” but others come to Him who “was declared to be the Son of God with power, according to the spirit of holiness;” and of these some with the “truly,” and some without it. …

St Augustine On Christian Doctrine, Christ the First Way to God

38. And mark that even when He who is Himself the Truth and the Word, by whom all things were made, had been made flesh that He might dwell among us, the apostle yet says: “Yea, though we have known Christ after the flesh, yet now henceforth know we Him no more.” For Christ, desiring not only to give the possession to those who had completed the journey, but also to be Himself the way to those who were just setting out, determined to take a fleshly body. Whence also that expression, “The Lord created me in the beginning of His way,” that is, that those who wished to come might begin their journey in Him. …

St Augustine Reply to Faustus the Manichæan, Faustus quotes passages to show that the Apostle Paul abandoned belief in the incarnation, to which he earlier held. Augustin shows that the apostle was consistent with himself in the utterances quoted

1. Faustus said: Assuredly I believe the apostle. And yet I do not believe that the Son of God was born of the seed of David according to the flesh, because I do not believe that God’s apostle could contradict himself, and have one opinion about our Lord at one time, and another at another. But, granting that he wrote this, since you will not hear of anything being spurious in his writings, it is not against us. For this seems to be Paul’s old belief about Jesus, when he thought, like everybody else, that Jesus was the son of David. Afterwards, when he learned that this was false, he corrects himself; and in his Epistle to the Corinthians he says: "We know no man after the flesh; yea, though we have known Christ after the flesh, yet now henceforth know we Him no more." Observe the difference between these two verses. …

St Augustine Reply to Faustus the Manichæan, Faustus quotes passages to show that the Apostle Paul abandoned belief in the incarnation, to which he earlier held. Augustin shows that the apostle was consistent with himself in the utterances quoted

8. The context of the passage containing this clause of which our adversaries make such a bad use, brings out its real meaning. "The love of Christ," we read, "constrains us, because we thus judge, that if one died for all, then all died; and He died for all, that they which live should not henceforth live unto themselves, but to Him who died for them, and rose again. Therefore henceforth know we no man after the flesh; and though we have known Christ after the flesh, yet now henceforth know we Him no more." The words, "that they which live should not henceforth live unto themselves, but unto Him who died for them, and rose again," show plainly that the resurrection of Christ is the ground of the apostle’s statement. …

St Augustine A Treatise on the Merits and Forgiveness of Sins, and on the Baptism of Infants, From the Epistles to the Corinthians

Likewise to the Corinthians he says: “For I delivered to you first of all that which I also received, how that Christ died for our sins according to the Scriptures.” Again, in his Second Epistle to these Corinthians: “For the love of Christ constraineth us; because we thus judge, that if One died for all, then all died: and for all did Christ die, that they which live should no longer live unto themselves, but unto Him which died for them, and rose again. Wherefore, henceforth know we no man after the flesh; yea, though we have known Christ after the flesh, yet from henceforth know we Him so no more. Therefore if any man be in Christ, he is a new creature; old things are passed away; behold, all things are become new. And all things are of God, who hath reconciled us to Himself by Jesus Christ, and hath given unto us the ministry of reconciliation. …

St Augustine Sermons on Selected Lessons of the New Testament, On the words of the Gospel, Matt. xx. 30, about the two blind men sitting by the way side, and crying out, ‘Lord, have mercy on us, Thou Son of David.’

14. For how are our eyes made whole? That as by faith we perceive Christ “passing by” in the temporal economy, so we may attain to the knowledge of Him as “standing still” in His unchangeable Eternity. For then is the eye made whole when the knowledge of Christ’s Divinity is attained. Let your love apprehend this; attend ye to the great mystery which I am to speak of. All the things which were done by our Lord Jesus Christ in time, graft faith in us. We believe on the Son of God, not on the Word only, “by which all things were made;” but on this very Word, “made flesh that He might dwell among us,” who was born of the Virgin Mary, and the rest which the Faith contains, and which are represented to us that Christ might “pass by,” and that the blind, hearing His footsteps as He “passeth by,” might by their works “cry out,” by their life exemplifying the profession of their faith. …

St Augustine Sermons on Selected Lessons of the New Testament, On the words of the Gospel, John xvi. 7, ‘I tell you the truth; it is expedient for you that I go away,’ etc

3. Now there would be no great merit and glorious blessedness in believing, if the Lord had always appeared in His Risen Body to the eyes of men. The Holy Ghost then hath brought this great gift to them that should believe, that Him whom they should not see with the eyes of flesh, they might with a mind sobered from carnal desires, and inebriated with spiritual longings, sigh after. Whence it was that when that disciple who had said that he would not believe, unless he touched with the hands His Scars, after he had handled the Lord’s Body, cried out as though awaking from sleep, “My Lord and my God;” the Lord said to him, “Because thou hast seen Me, thou hast believed; blessed are they that have not seen, and yet have believed.” This blessedness hath the Holy Ghost, the Comforter, brought to us, that the form of a servant which He took from the Virgin’s womb, being removed from the eyes …

St Augustine Lectures or Tractates on the Gospel According to St. John, Chapter XVI. 4-7

4. “But because I have said these things unto you,” He adds, “sorrow hath filled your heart.” He saw, indeed, what effect these words of His were producing in their hearts; for having not yet within them the spiritual consolation, which they were afterwards to have by the Holy Spirit, what they still saw objectively in Christ they were afraid of losing; and because they could have no doubt they were about to lose Him whose announcements were always true, their human feelings were saddened, because their carnal view of Him was to be left a blank. But He knew what was most expedient for them, because that inward sight, wherewith the Holy Spirit was yet to comfort them, was undoubtedly superior; not by bringing a human body into the bodies of those who saw, but by infusing Himself into the hearts of those who believed. …

12 more passages of the Fathers cite this verse. The Motif Searcher in the palace lists them all.