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Genesis 28:14

And thy seed shall be as the dust of the earth: thou shalt spread abroad to the west, and to the east, and to the north, and to the south: and IN THEE and thy seed all the tribes of the earth SHALL BE BLESSED.

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The verse in its languages

Vulgate (Clementine)
Eritque semen tuum quasi pulvis terræ : dilataberis ad occidentem, et orientem, et septentrionem, et meridiem : et benedicentur in te et in semine tuo cunctæ tribus terræ.
Septuagint (Swete)
καὶ ἔσται τὸ σπέρμα σου ὡς ἡ ἄμμος τῆς θαλάσσης, καὶ πλατυνθήσεται ἐπὶ θάλασσαν καὶ ἐπὶ λίβα καὶ ἐπὶ βορρᾶν καὶ ἐπ᾽ ἀνατολάς· ⸆ καὶ ἐνευλογηθήσονται ἐν σοὶ πᾶσαι αἱ φυλαὶ τῆς γῆς καὶ ἐν τῷ σπέρματί σου.
Hebrew (WLC)
וְהָיָ֤ה זַרְעֲךָ֙ כַּעֲפַ֣ר הָאָ֔רֶץ וּפָרַצְתָּ֛ יָ֥מָּה וָקֵ֖דְמָה וְצָפֹ֣נָה וָנֶ֑גְבָּה וְנִבְרֲכ֥וּ בְךָ֛ כָּל מִשְׁפְּחֹ֥ת הָאֲדָמָ֖ה וּבְזַרְעֶֽךָ

The Fathers on this verse

St Ignatius of Antioch Epistle to the Magnesians: Shorter and, Chapter X. Beware of Judaizing

Let us not, therefore, be insensible to His kindness. For were He to reward us according to our works, we should cease to be. For “if Thou, Lord, shalt mark iniquities, O Lord, who shall stand?” Let us therefore prove ourselves worthy of that name which we have received. For whosoever is called by any other name besides this, he is not of God; for he has not received the prophecy which speaks thus concerning us: “The people shall be called by a new name, which the Lord shall name them, and shall be a holy people.” This was first fulfilled in Syria; for “the disciples were called Christians at Antioch,” when Paul and Peter were laying the foundations of the Church. Lay aside, therefore, the evil, the old, the corrupt leaven, and be ye changed into the new leaven of grace. Abide in Christ, that the stranger may not have dominion over you. …

St Justin Martyr Dialogue with Trypho, Chapter CXX. Christians were

“Observe, too, how the same promises are made to Isaac and to Jacob. For thus He speaks to Isaac: ‘And in thy seed shall all the nations of the earth be blessed.’ And to Jacob: ‘And in thee and in thy seed shall all families of the earth be blessed.’ He says that neither to Esau nor to Reuben, nor to any other; only to those of whom the Christ should arise, according to the dispensation, through the Virgin Mary. But if you would consider the blessing of Judah, you would perceive what I say. For the seed is divided from Jacob, and comes down through Judah, and Phares, and Jesse, and David. …

Tertullian The Five Books Against Marcion, Christ's Millennial and Heavenly Glory in Company with His Saints

Yes, certainly, you say, I do hope from Him that which amounts in itself to a proof of the diversity (of Christs), God’s kingdom in an everlasting and heavenly possession. Besides, your Christ promises to the Jews their primitive condition, with the recovery of their country; and after this life’s course is over, repose in Hades in Abraham’s bosom. Oh, most excellent God, when He restores in amnesty what He took away in wrath! Oh, what a God is yours, who both wounds and heals, creates evil and makes peace! Oh, what a God, that is merciful even down to Hades! I shall have something to say about Abraham’s bosom in the proper place. …

St Augustine City of God, Of Jacob’s Mission to Mesopotamia to Get a Wife, and of the Vision Which He Saw in a Dream by the Way, and of His Getting Four Women When He Sought One Wife

When Jacob was going to Mesopotamia, he received in a dream an oracle, of which it is thus written: “And Jacob went out from the well of the oath, and went to Haran. And he came to a place, and slept there, for the sun was set; and he took of the stones of the place, and put them at his head, and slept in that place, and dreamed. And behold a ladder set up on the earth, and the top of it reached to heaven; and the angels of God ascended and descended by it. And the Lord stood above it, and said, I am the God of Abraham thy father, and the God of Isaac; fear not: the land whereon thou sleepest, to thee will I give it, and to thy seed; and thy seed shall be as the dust of the earth; and it shall be spread abroad to the sea, and to Africa, and to the north, and to the east: and all the tribes of the earth shall be blessed in thee and in thy seed. …

St Augustine Reply to Faustus the Manichæan, Faustus denies that the prophets predicted Christ. Augustin proves such prediction from the New Testament, and expounds at length the principal types of Christ in the Old Testament

26. Who in the angel striving with Jacob, on the one hand is constrained to give him a blessing, as the weaker to the stronger, the conquered to the conqueror, and on the other hand puts his thigh-bone out of joint, but He who, when He suffered the people of Israel to prevail against Him, blessed those among them who believed, while the multitude, like Jacob’s thigh-bone, halted in their carnality? Who is the stone placed under Jacob’s head, but Christ the head of man? And in its anointing the very name of Christ is expressed, for, as all know, Christ means anointed. …

St Augustine Reply to Faustus the Manichæan, Faustus denies that the prophets predicted Christ. Augustin proves such prediction from the New Testament, and expounds at length the principal types of Christ in the Old Testament

41. Besides this wonderful agreement between the types and the things typified, the adversary may be convinced by plain prophetic intimations, such as this: "In thy seed shall all nations be blessed." This was said to Abraham, and again to Isaac, and again to Jacob. Hence the significance of the words "I am the God of Abraham, and Isaac, and Jacob." God fulfills His promise to their seed in blessing all nations. With a like significance, Abraham himself, when he made his servant swear, told him to put his hand under his thigh; for he knew that thence would come the flesh of Christ, in whom we have now, not the promise of blessing to all nations, but the promise fulfilled.

St Augustine The Harmony of the Gospels, Of the Fact that the God of the Hebrews, Although the People Were Conquered, Proved Himself to Be Unconquered, by Overthrowing the Idols, and by Turning All the Gentiles to His Own Service

21. Here indeed we have a wonderful fact, which is not remarked by those few pagans who have remained such, namely, that this God of the Hebrews who was offended by the conquered, and who was also denied acceptance by the conquerors, is now preached and worshipped among all nations. This is that God of Israel of whom the prophet spake so long time since, when he thus addressed the people of God: “And He who brought thee out, the God of Israel, shall be called (the God) of the whole earth.” What was thus prophesied has been brought to pass through the name of the Christ, who comes to men in the form of a descendant of that very Israel who was the grandson of Abraham, with whom the race of the Hebrews began. …

St Augustine Lectures or Tractates on the Gospel According to St. John, Chapter I. 34-51

23. Already on a former occasion I have spoken of these ascending and descending angels; but lest you should have forgotten, I shall speak of the latter briefly by way of recalling it to your recollection. I should use more words if I were introducing, not recalling the subject. Jacob saw a ladder in a dream; and on a ladder he saw angels ascending and descending: and he anointed the stone which he had placed at his head. You have heard that the Messias is Christ; you have heard that Christ is the Anointed. For Jacob did not place the stone, the anointed stone, that he might come and adore it: otherwise that would have been idolatry, not a pointing out of Christ. What was done was a pointing out of Christ, so far as it behoved such a pointing out to be made, and it was Christ that was pointed out. A stone was anointed, but not for an idol. …

St Augustine Expositions on the Book of Psalms, Psalm XLV

18. This was figured in Jacob’s placing a stone at his head, and so sleeping. The patriarch Jacob had placed a stone at his head: sleeping with that stone at his head, he saw heaven opened, and a ladder from heaven to earth, and Angels ascending and descending; after this vision he awaked, anointed the stone, and departed. In that “stone” he understood Christ; for that reason he anointed it. Take notice what it is whereby Christ is preached. What is the meaning of that anointing of a stone, especially in the case of the Patriarchs who worshipped but One God? It was however done as a figurative act: and he departed. For he did not anoint the stone, and come to worship there constantly, and to perform sacrifice there. It was the expression of a mystery; not the commencement of sacrilege. …

The Fathers are given as they wrote. Where a passage lays the Passion on the Jewish people, the Church teaches that it cannot be charged against all the Jews then living, nor against the Jews of today, and that all sinners were its authors (CCC 597, 598).

The Catechism cites this verse