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Genesis 3:22

And he said: Behold Adam is become as one of us, knowing good and evil: now, therefore, lest perhaps he put forth his hand, and take also of the tree of life, and eat, and live for ever.

Challoner: Behold AdamThis was spoken by way of reproaching him with his pride, in affecting a knowledge that might make him like to God.
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The verse in its languages

Vulgate (Clementine)
et ait : Ecce Adam quasi unus ex nobis factus est, sciens bonum et malum : nunc ergo ne forte mittat manum suam, et sumat etiam de ligno vitæ, et comedat, et vivat in æternum.
Septuagint (Swete)
Καὶ εἶπεν Κύριος ὁ θεός Ἰδοὺ Ἀδὰμ γέγονεν ὡς εἷς ἐξ ἡμῶν, τοῦ γινώσκειν καλὸν καὶ πονηρόν· καὶ νῦν μή ποτε ἐκτείνῃ τὴν χεῖρα καὶ λάβῃ τοῦ ξύλου τῆς ζωῆς καὶ φάγῃ, καὶ ζήσεται εἰς τὸν αἰῶνα.
Hebrew (WLC)
וַיֹּ֣אמֶר יְהוָ֣ה אֱלֹהִ֗ים הֵ֤ן הָֽאָדָם֙ הָיָה֙ כְּאַחַ֣ד מִמֶּ֔נּוּ לָדַ֖עַת ט֣וֹב וָרָ֑ע וְעַתָּ֣ה פֶּן יִשְׁלַ֣ח יָד֗וֹ וְלָקַח֙ גַּ֚ם מֵעֵ֣ץ הַֽחַיִּ֔ים וְאָכַ֖ל וָחַ֥י לְעֹלָֽם

Haydock's commentary

Behold Adam, &c. This was spoken by way of reproaching him with his pride, in affecting a knowledge that might make him like to God. (Challoner)

"These are the words of God, not insulting over man, but deterring others from an imitation of his pride." (St. Augustine, de Gen. xi. 39.)

For ever. The sentence is left imperfect: (Calmet) but by driving man from Paradise, God sufficiently shewed how he would prevent him from eating of the tree of life, (Haydock) which Adam had not yet found. As he was now condemned to be miserable on earth, God, in mercy, prevented him from tasting of that fruit, which would have rendered his misery perpetual. (Menochius)

He would suffer him to die, that, by death, he might come, after a life of 930 years, spent in sorrow and repentance, to the enjoyment of himself. (Haydock)

Lest perhaps. God does not exercise his absolute power, or destroy free-will, but makes use of ordinary means and precautions, to effect his designs. (St. Augustine) (Worthington)

From Haydock's Catholic Bible Commentary, 1859, in the transcription made by Todd Easton and kept online by John Paul Wohlschied at johnblood.gitlab.io/haydock.

The Fathers on this verse

St Justin Martyr Dialogue with Trypho, Chapter LXII. The words “Let Us

“And the same sentiment was expressed, my friends, by the word of God [written] by Moses, when it indicated to us, with regard to Him whom it has pointed out, that God speaks in the creation of man with the very same design, in the following words: ‘Let Us make man after our image and likeness. And let them have dominion over the fish of the sea, and over the fowl of the heaven, and over the cattle, and over all the earth, and over all the creeping things that creep on the earth. And God created man: after the image of God did He create him; male and female created He them. …

St Justin Martyr Dialogue with Trypho, Chapter CXXIX. That is confirmed

“And now I shall again recite the words which I have spoken in proof of this point. When Scripture says, ‘The Lord rained fire from the Lord out of heaven,’ the prophetic word indicates that there were two in number: One upon the earth, who, it says, descended to behold the cry of Sodom; Another in heaven, who also is Lord of the Lord on earth, as He is Father and God; the cause of His power and of His being Lord and God. Again, when the Scripture records that God said in the beginning, ‘Behold, Adam has become like one of Us,’ this phrase, ‘like one of Us,’ is also indicative of number; and the words do not admit of a figurative meaning, as the sophists endeavour to affix on them, who are able neither to tell nor to understand the truth. And it is written in the book of Wisdom: ‘If I should tell you daily events, I would be mindful to enumerate them from the beginning. …

Tertullian The Five Books Against Marcion, God's Dealings with Adam at the Fall, and with Cain After His Crime, Admirably Explained and Defended

It is now high time that I should, in order to meet all objections of this kind, proceed to the explanation and clearing up of the other trifles, weak points, and inconsistencies, as you deemed them. God calls out to Adam, Where art thou? as if ignorant where he was; and when he alleged that the shame of his nakedness was the cause (of his hiding himself), He inquired whether he had eaten of the tree, as if He were in doubt. By no means; God was neither uncertain about the commission of the sin, nor ignorant of Adam’s whereabouts. It was certainly proper to summon the offender, who was concealing himself from the consciousness of his sin, and to bring him forth into the presence of his Lord, not merely by the calling out of his name, but with a home-thrust blow at the sin which he had at that moment committed. …

Tertullian On the Resurrection of the Flesh, Conclusion. The Resurrection of the Flesh in Its Absolute Identity and Perfection. Belief of This Had Become Weak. Hopes for Its Refreshing Restoration Under the Influences of the Paraclete

And so the flesh shall rise again, wholly in every man, in its own identity, in its absolute integrity. Wherever it may be, it is in safe keeping in God’s presence, through that most faithful “Mediator between God and man, (the man) Jesus Christ,” who shall reconcile both God to man, and man to God; the spirit to the flesh, and the flesh to the spirit. Both natures has He already united in His own self; He has fitted them together as bride and bridegroom in the reciprocal bond of wedded life. Now, if any should insist on making the soul the bride, then the flesh will follow the soul as her dowry. The soul shall never be an outcast, to be had home by the bridegroom bare and naked. She has her dower, her outfit, her fortune in the flesh, which shall accompany her with the love and fidelity of a foster-sister. …

Tertullian Against Praxeas, Other Quotations from Holy Scripture Adduced in Proof of the Plurality of Persons in the Godhead

If the number of the Trinity also offends you, as if it were not connected in the simple Unity, I ask you how it is possible for a Being who is merely and absolutely One and Singular, to speak in plural phrase, saying, “Let us make man in our own image, and after our own likeness;” whereas He ought to have said, “Let me make man in my own image, and after my own likeness,” as being a unique and singular Being? In the following passage, however, “Behold the man is become as one of us,” He is either deceiving or amusing us in speaking plurally, if He is One only and singular. …

St Methodius The Banquet of the Ten Virgins; or Concerning Chastity, Chapter III

And, first, we must inquire if Adam can be likened to the Son of God, when he was found in the transgression of the Fall, and heard the sentence, “Dust thou art, and unto dust shalt thou return.” For how shall he be considered “the first-born of every creature,” who, after the creation of the earth and the firmament, was formed out of clay? And how shall he be admitted to be “the tree of life” who was cast out for his transgression, lest “he should again stretch forth his hand and eat of it, and live forever?” For it is necessary that a thing which is likened unto anything else, should in many respects be similar and analogous to that of which it is the similitude, and not have its constitution opposite and dissimilar. For one who should venture to compare the uneven to the even, or harmony to discord, would not be con sidered rational. …

St Augustine Expositions on the Book of Psalms, Psalm LXXIV

15. “Thou hast dried up the rivers of Etham” ( ver. 15 ).…What is Etham? For the word is Hebrew. What is Etham interpreted? Strong, stout. Who is this strong and stout one, whose rivers God drieth up? Who but that very dragon? For “no one entereth into the house of a strong man that he may spoil his vessels, unless first he shall have bound fast the strong man.” This is that strong man on his own virtue relying, and forsaking God: this is that strong man, who saith, “I will set my seat by the north, and I will be like the Most High.” Out of that very cup of perverse strength he hath given man to drink. Strong they willed to be, who thought that they would be Gods by means of the forbidden food. …

St John Chrysostom The Homilies of St. John Chrysostom, Matthew V. 1, 2

3. For whereas the greatest of evils, and those which make havoc of the whole world, had their entering in from pride: for both the devil, not being such before, did thus become a devil; as indeed Paul plainly declared, saying, “Lest being lifted up with pride, he fall into the condemnation of the devil:”, and the first man, too, puffed up by the devil with these hopes, was made an example of,and became mortal (for expecting to become a god, he lost even what he had; and God also upbraiding him with this, and mocking his folly, said, “Behold, Adam is become as one of us”; and each one of those that came after did hereby wreck himself in impiety, fancying some equality with God: since, I say, this was the stronghold of our evils, and the root and fountain of all wickedness, He, preparing a remedy suitable to the disease, laid this law first as a strong and safe foundation. …

St John Chrysostom The Homilies of St. John Chrysostom, Matthew IX. 9

And this He saith unto them in irony; as when He said, “Behold, Adam is become as one of us;”and again, “If I were hungry, I would not tell thee.” For that no man on earth was righteous, Paul declared, saying, “For all have sinned, and come short of the glory of God.” And by this too the others were comforted, I mean, the guests. “Why, I am so far,” saith He, “from loathing sinners, that even for their sakes only am I come.” Then, lest He should make them more careless, He staid not at the word “sinners,” but added, “unto repentance.” “For I am not come that they should continue sinners, but that they should alter, and amend.”

St Gregory Nazianzen In Defence of His Flight to Pontus, and His Return, After His Ordination to the Priesthood, with an Exposition of the Character of the Priestly Office

25. This is why the heathen rage and the peoples imagine vain things; why tree is set over against tree, hands against hand, the one stretched out in self indulgence, the others in generosity; the one unrestrained, the others fixed by nails, the one expelling Adam, the other reconciling the ends of the earth. This is the reason of the lifting up to atone for the fall, and of the gall for the tasting, and of the thorny crown for the dominion of evil, and of death for death, and of darkness for the sake of light, and of burial for the return to the ground, and of resurrection for the sake of resurrection. All these are a training from God for us, and a healing for our weakness, restoring the old Adam to the place whence he fell, and conducting us to the tree of life, from which the tree of knowledge estranged us, when partaken of unseasonably, and improperly.

St John Cassian The Conferences of John Cassian. Part II. Containing Conferences XI-XVII, Chapter XII. That a good will should not always be attributed to grace, nor always to man himself

For we should not hold that God made man such that he can never will or be capable of what is good: or else He has not granted him a free will, if He has suffered him only to will or be capable of evil, but neither to will or be capable of what is good of himself. And, in this case how will that first statement of the Lord made about men after the fall stand: “Behold, Adam is become as one of us, knowing good and evil?” For we cannot think that before, he was such as to be altogether ignorant of good. Otherwise we should have to admit that he was formed like some irrational and insensate beast: which is sufficiently absurd and altogether alien from the Catholic faith. Moreover as the wisest Solomon says: “God made man upright,” i.e., always to enjoy the knowledge of good only, “But they have sought out many imaginations,” for they came, as has been said, to know good and evil. …