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Genesis 49:3

Ruben, my firstborn, thou art my strength, and the beginning of my sorrow: excelling in gifts, greater in command.

Challoner: My strengthHe calls him his strength, as being born whilst his father was in his full strength and vigour: he calls him the beginning of his sorrow, because cares and sorrows usually come on with the birth of children. Excelling in gifts, etc., because the firstborn had a title to a double portion, and to have the command over his brethren, which Ruben forfeited by his sin; being poured out as water, that is, spilt and lost.
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The verse in its languages

Vulgate (Clementine)
Ruben, primogenitus meus, tu fortitudo mea, et principium doloris mei ; prior in donis, major in imperio.
Septuagint (Swete)
Ῥουβὴν πρωτότοκός μου, σὺ ἰσχύς μου καὶ ἀρχὴ τέκνων μου· σκληρὸς φέρεσθαι καὶ σκληρὸς αὐθάδης.
Hebrew (WLC)
רְאוּבֵן֙ בְּכֹ֣רִי אַ֔תָּה כֹּחִ֖י וְרֵאשִׁ֣ית אוֹנִ֑י יֶ֥תֶר שְׂאֵ֖ת וְיֶ֥תֶר עָֽז

Haydock's commentary

My strength, &c. He calls him his strength, as being born whilst his father was in his full strength and vigour: he calls him the beginning of his sorrow, because cares and sorrows usually come on with the birth of children.

Excelling in gifts, &c., because the first-born had a title to a double portion, and to have the command over his brethren, which Ruben forfeited by his sin; being poured out as water; that is, spilt and lost. (Challoner)

In command. He ought to have succeeded to his father in authority. But Joseph entered in upon his rejection, 1 Paralipomenon v. 1. The priesthood was given to Levi's descendants; and the regal power, partly to those of Joseph, who reigned over the ten tribes, for a long time; and partly to the posterity of Juda, who exercised dominion over all the people of Israel. (Chaldee) (Worthington)

From Haydock's Catholic Bible Commentary, 1859, in the transcription made by Todd Easton and kept online by John Paul Wohlschied at johnblood.gitlab.io/haydock.

The Fathers on this verse

Origen A Letter from Origen to Africanus

And as to an appearance (which is better than a dream), he speaks as follows about himself: “And Jacob was left alone; and there wrestled a man with him until the breaking of the day. And he saw that he prevailed not against him, and he touched the breadth of his thigh; and the breadth of Jacob’s thigh grew stiff while he was wrestling with him. And he said to him, Let me go, for the day breaketh. And he said, I will not let thee go, except thou bless me. And he said unto him, What is thy name? And he said, Jacob. And he said to him, Thy name shall be called no more Jacob, but Israel shall be thy name: for thou hast prevailed with God, and art powerful with men. And Jacob asked him, and said, Tell me thy name. And he said, Wherefore is it that thou dost ask after my name? And he blessed him there. …

St Hippolytus On Genesis, Section I

Gen. xlix. 3 Reuben, my first-born, thou art my strength, and the first of my children; hard to bear with, and hard and self-willed: thou hast waxed wanton as water; boil not over.

St Augustine Expositions on the Book of Psalms, Psalm LXXVIII

34. “And He rejected,” he saith, “the tabernacle of Joseph, and the tribe of Ephraim He chose not” ( ver. 68 ). “And He chose the tribe of Judah” ( ver. 69 ). He hath not said, He rejected the tabernacle of Reuben, who was the first-born son of Jacob; nor them that follow, and precede Judah in order of birth; so that they being rejected and not chosen, the tribe of Judah was chosen. For it might have been said that they were deservedly rejected; because even in the blessing of Jacob wherewith he blessed his sons, he mentioneth their sins, and deeply abhorreth them; though among them the tribe of Levi merited to be the priestly tribe, whence also Moses was. …

St Athanasius Against the Arians. (Orationes contra Arianos IV.), Texts explained; Sixthly, Proverbs viii. 22. Proverbs are of a figurative nature, and must be interpreted as such. We must interpret them, and in particular this passage, by the Regula Fidei. 'He created me' not equivalent to 'I am a creature.' Wisdom a creature so far forth as Its human body. Again, if He is a creature, it is as 'a beginning of ways,' an office which, though not an attribute, is a consequence, of a higher and divine nature. And it is 'for the works,' which implied the works existed, and therefore much more He, before He was created. Also 'the Lord' not the Father 'created' Him, which implies the creation was that of a servant

48. For if He is Offspring, how call ye Him creature? for no one says that He begets what He creates, nor calls His proper offspring creatures; and again, if He is Only-begotten, how becomes He ‘beginning of the ways?’ for of necessity, if He was created a beginning of all things, He is no longer alone, as having those who came into being after Him. For Reuben, when he became a beginning of the children, was not only-begotten, but in time indeed first, but in nature and relationship one among those who came after him. Therefore if the Word also is ‘a beginning of the ways,’ He must be such as the ways are, and the ways must be such as the Word, though in point of time He be created first of them. …

Aphrahat Aphrahat: Select Demonstrations, Of the Resurrection of the Dead

8. Thus also Joseph bound his brethren by an oath, and said to them: When God shall remember you, take up my bones from hence with you. And according to the word of Joseph his brethren did, and kept the oath a hundred and twenty-five years. At that time when the hosts of the Lord went out from the land of Egypt, then Moses took up the bones of Joseph when he went forth. And the bones of the righteous man were more precious and better in his estimation than the gold and the silver that the children of Israel took from Egypt when they spoiled them. And the bones of Joseph were forty years in the wilderness; and at that time when Moses fell asleep, he gave them in inheritance to Joshua the son of Nun. The bones of Joseph his father were better in his estimation than all the spoil of that land which he subdued. …