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Isaias 1:4

Woe to the sinful nation, a people laden with iniquity, a wicked seed, ungracious children: they have forsaken the Lord, they have blasphemed the Holy One of Israel, they are gone away backwards.

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The verse in its languages

Vulgate (Clementine)
Væ genti peccatrici, populo gravi iniquitate, semini nequam, filiis sceleratis ! dereliquerunt Dominum ; blasphemaverunt Sanctum Israël ; abalienati sunt retrorsum.
Septuagint (Swete)
οὐαὶ ἔθνος ἁμαρτωλόν, λαὸς πλήρης ἁμαρτιῶν, σπέρμα πονηρόν, υἱοὶ ἄνομοι. ἐγκατελίπατε τὸν κύριον καὶ παρωργίσατε τὸν ἅγιον τοῦ Ἰσραήλ.
Hebrew (WLC)
ה֣וֹי גּ֣וֹי חֹטֵ֗א עַ֚ם כֶּ֣בֶד עָוֺ֔ן זֶ֣רַע מְרֵעִ֔ים בָּנִ֖ים מַשְׁחִיתִ֑ים עָזְב֣וּ אֶת יְהוָ֗ה נִֽאֲצ֛וּ אֶת קְד֥וֹשׁ יִשְׂרָאֵ֖ל נָזֹ֥רוּ אָחֽוֹר

The Fathers on this verse

Clement of Alexandria The Instructor, Chapter IX. That It is the Prerogative of the Same Power to Be Beneficent and to Punish Justly. Also the Manner of the Instruction of the Logos

Reproof is the bringing forward of sin, laying it before one. This form of instruction He employs as in the highest degree necessary, by reason of the feebleness of the faith of many. For He says by Esaias, “Ye have forsaken the Lord , and have provoked the Holy One of Israel to anger.” And He says also by Jeremiah: “Heaven was astonished at this, and the earth shuddered exceedingly. For My people have committed two evils; they have forsaken Me, the fountain of living waters, and have hewn out to themselves broken cisterns, which will not be able to hold water.” And again, by the same: “Jerusalem hath sinned a sin; therefore it became commotion. …

Clement of Alexandria The Instructor, Chapter IX. That It is the Prerogative of the Same Power to Be Beneficent and to Punish Justly. Also the Manner of the Instruction of the Logos

Denunciation is vehement speech. And He employs denunciation as medicine, by Isaiah, saying, “Ah, sinful nation, lawless sons, people full of sins, wicked seed!” And in the Gospel by John He says, “Serpents, brood of vipers.”

Tertullian An Answer to the Jews, Of Circumcision and the Supercession of the Old Law

But Abraham, (you say) was circumcised. Yes, but he pleased God before his circumcision; nor yet did he observe the Sabbath. For he had “accepted” circumcision; but such as was to be for “a sign” of that time, not for a prerogative title to salvation. In fact, subsequent patriarchs were uncircumcised, like Melchizedek, who, uncircumcised, offered to Abraham himself, already circumcised, on his return from battle, bread and wine. “But again,” (you say) “the son of Moses would upon one occasion have been choked by an angel, if Zipporah, had not circumcised the foreskin of the infant with a pebble; whence, “there is the greatest peril if any fail to circumcise the foreskin of his flesh.” Nay, but if circumcision altogether brought salvation, even Moses himself, in the case of his own son, would not have omitted to circumcise him on the eighth day; whereas it is agreed that Zipporah did it o …

Tertullian An Answer to the Jews, Argument from the Destruction of Jerusalem and Desolation of Judea

This “wood,” again, Isaac the son of Abraham personally carried for his own sacrifice, when God had enjoined that he should be made a victim to Himself. But, because these had been mysteries which were being kept for perfect fulfilment in the times of Christ, Isaac, on the one hand, with his “wood,” was reserved, the ram being of fered which was caught by the horns in the bramble; Christ, on the other hand, in His times, carried His “wood” on His own shoulders, adhering to the horns of the cross, with a thorny crown encircling His head. …

Tertullian The Five Books Against Marcion, Community in Certain Points of Marcionite and Jewish Error. Prophecies of Christ's Rejection Examined

Since, therefore, there clearly exist these two characteristics in the Jewish prophetic literature, let the reader remember, whenever we adduce any evidence therefrom, that, by mutual consent, the point of discussion is not the form of the scripture, but the subject it is called in to prove. When, therefore, our heretics in their phrenzy presumed to say that that Christ was come who had never been fore-announced, it followed that, on their assumption, that Christ had not yet appeared who had always been predicted; and thus they are obliged to make common cause with Jewish error, and construct their arguments with its assistance, on the pretence that the Jews were themselves quite certain that it was some other who came: so they not only rejected Him as a stranger, but slew Him as an enemy, although they would without doubt have acknowledged Him, and with all religious devotion followed H …

Tertullian The Five Books Against Marcion, The Dispersion of the Jews, and Their Desolate Condition for Rejecting Christ, Foretold

Now, since you join the Jews in denying that their Christ has come, recollect also what is that end which they were predicted as about to bring on themselves after the time of Christ, for the impiety wherewith they both rejected and slew Him. For it began to come to pass from that day, when, according to Isaiah, “a man threw away his idols of gold and of silver, which they made into useless and hurtful objects of worship;” in other words, from the time when he threw away his idols after the truth had been made clear by Christ. Consider whether what follows in the prophet has not received its fulfilment: “The Lord of hosts hath taken away from Judah and from Jerusalem, amongst other things, both the prophet and the wise artificer;” that is, His Holy Spirit, who builds the church, which is indeed the temple, and household and city of God. …

St Cyprian Three Books of Testimonies Against the Jews, Testimony III

In Isaiah: “Hear, O heaven, and give ear, O earth: for the Lord hath spoken; I have begotten and brought up children, but they have rejected me. The ox knoweth his owner, and the ass his master’s crib: but Israel hath not known me, and my people hath not perceived me. Ah sinful nation, a people filled with sins, a wicked seed, corrupting children: ye have forsaken the Lord, and have sent that Holy One of Israel into anger.” In the same also the Lord says: “Go and tell this people, Ye shall hear with the ear, and shall not understand; and seeing, ye shall see, and shall not perceive. …

St John Chrysostom Homilies on Second Corinthians, Homily II

[7.] Then beginning the prayer, he saith, “That the all-pitying and merciful God would listen to their prayers.” For that thou mayest not say, What shall we pray? they are aliens, not yet united [to the body]. Whereby can I constrain the regard of God? Whence can I prevail with Him to impart unto them mercy and forgiveness? That thou mayest not be perplexed with such questions as these, see how he disentangleth thy perplexity, saying, “that the all-pitying and merciful God.” Heardest thou? “All-pitying God.” Be perplexed no more. For the All-pitying pitieth all, both sinners and friends. Say not then, “How shall I approach Him for them?” Himself will listen to their prayers. And the Catechumens’ prayer, what can it be but that they may not remain Catechumens? Next, he suggesteth also the manner of the prayer. …

St Athanasius Letters of Athanasius with Two Ancient Chronicles of His Life, Second Letter to Lucifer

Although I believe that tidings have reached your holiness also of the persecution which the enemies of Christ have just now attempted to raise, seeking our blood, yet our own most beloved messengers can tell your piety about it. For to such a length did they dare to carry their madness by means of the soldiers, that they not only banished the Clergy of the city, but also went out to the Hermits, and laid their fatal hands upon Solitaries. Hence I also withdrew far away, lest those who entertained me should suffer trouble at their hands. …

The Fathers are given as they wrote. Where a passage lays the Passion on the Jewish people, the Church teaches that it cannot be charged against all the Jews then living, nor against the Jews of today, and that all sinners were its authors (CCC 597, 598).

The Catechism cites this verse