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The verse in its languages

Vulgate (Clementine)
Ego sum panis vivus, qui de cælo descendi.
Greek New Testament (SBLGNT)
ἐγώ εἰμι ὁ ἄρτος ὁ ζῶν ὁ ἐκ τοῦ οὐρανοῦ καταβάς· ἐάν τις φάγῃ ἐκ τούτου τοῦ ἄρτου ζήσει εἰς τὸν αἰῶνα, καὶ ὁ ἄρτος δὲ ὃν ἐγὼ δώσω ἡ σάρξ μού ἐστιν ὑπὲρ τῆς τοῦ κόσμου ζωῆς.

Haydock's commentary

Christ now no longer calls the belief in him, or the preaching of the gospel, the bread that he will give them; but he declares that it is his own flesh, and that flesh which shall be given for the life of the world. (Calmet)

This bread Christ then gave, when he gave the mystery of his body and blood to his disciples. (Ven. Bede)

From Haydock's Catholic Bible Commentary, 1859, in the transcription made by Todd Easton and kept online by John Paul Wohlschied at johnblood.gitlab.io/haydock.

The Fathers on this verse

Clement of Alexandria The Instructor, Chapter VI. The Name Children Does Not Imply Instruction in Elementary Principles

Further, the Word declares Himself to be the bread of heaven. “For Moses,” He says, “gave you not that bread from heaven, but My Father giveth you the true bread from heaven. For the bread of God is He that cometh down from heaven, and giveth life to the world. And the bread which I will give is My flesh, which I will give for the life of the world.” Here is to be noted the mystery of the bread, inasmuch as He speaks of it as flesh, and as flesh, consequently, that has risen through fire, as the wheat springs up from decay and germination; and, in truth, it has risen through fire for the joy of the Church, as bread baked. But this will be shown by and by more clearly in the chapter on the resurrection. …

Tertullian On the Flesh of Christ, Christ's Human Nature. The Flesh and the Soul Both Fully and Unconfusedly Contained in It

The soul became flesh that the soul might become visible. Well, then, did the flesh likewise become soul that the flesh might be manifested? If the soul is flesh, it is no longer soul, but flesh. If the flesh is soul, it is no longer flesh, but soul. Where, then, there is flesh, and where there is soul, it has become both one and the other. Now, if they are neither in particular, although they become both one and the other, it is, to say the least, very absurd, that we should understand the soul when we name the flesh, and when we indicate the soul, explain ourselves as meaning the flesh. All things will be in danger of being taken in a sense different from their own proper sense, and, whilst taken in that different sense, of losing their proper one, if they are called by a name which differs from their natural designation. Fidelity in names secures the safe appreciation of properties. …

Tertullian On the Resurrection of the Flesh, Christ's Assertion About the Unprofitableness of the Flesh Explained Consistently with Our Doctrine

He says, it is true, that “the flesh profiteth nothing;” but then, as in the former case, the meaning must be regulated by the subject which is spoken of. Now, because they thought His discourse was harsh and intolerable, supposing that He had really and literally enjoined on them to eat his flesh, He, with the view of ordering the state of salvation as a spiritual thing, set out with the principle, “It is the spirit that quickeneth;” and then added, “The flesh profiteth nothing,”, meaning, of course, to the giving of life. …

Novatian A Treatise of Novatian Concerning the Trinity, Chapter XIV

And yet the heretic still shrinks from urging that Christ is God, whom he perceives to be proved God by so many words as well as facts. If Christ is only man, how, when He came into this world, did He come unto His own, since a man could have made no world? If Christ was only man, how is the world said to have been made by Him, when the world was not by man, but man was ordained after the world? If Christ was only man, how was it that Christ was not only of the seed of David; but He was the Word made flesh and dwelt among us? For although the Protoplast was not born of seed, yet neither was the Protoplast formed of the conjunction of the Word and the flesh. For He is not the Word made flesh, nor dwelt in us. …

Origen Origen's Commentary on Matthew, Chapter XIV

After this, it is worth while to look at the phrase which has been assailed in a sophistical way by those who say that the God of the law and the God of the Gospel of Jesus Christ is not the same; for they say that the heavenly Father of Jesus Christ is not the husbandman of those who think that they worship God according to the law of Moses. Jesus Himself said that the Pharisees, who were worshipping the God who created the world and the law, were not a plant which His heavenly Father had planted, and that for this reason it was being rooted up. …

Origen Origen's Commentary on Matthew, Chapter V

“ And His disciples came to the other side and forgot to take loaves. ” Since the loaves which they had before they came to the other side were no longer useful to the disciples when they came to the other side, for they needed one kind of loaves before they crossed and a different kind when they crossed, on this account, being careless of taking loaves when going to the other side, they forgot to take loaves with them. To the other side then came the disciples of Jesus who had passed over from things material to things spiritual, and from things sensible to those which are intellectual. …

Origen Origen's Commentary on Matthew, Chapter XXXIII

But we must seek to understand what is meant by “tasting of death.” And He is life who says, “I am the life,” and this life assuredly has been hidden with Christ in God; and. “when Christ our life shall be manifested, then along with Him” shall be manifested those who are worthy of being manifested with Him in glory. But the enemy of this life, who is also the last enemy of all His enemies that shall be destroyed, is death, of which the soul that sinneth dies, having the opposite disposition to that which takes place in the soul that lives uprightly, and in consequence of living uprightly lives. And when it is said in the law, “I have placed life before thy face,” the Scripture says this about Him who said, “I am the Life,” and about His enemy, death; the one or other of which each of us by his deeds is always choosing. …

St Augustine City of God, Of Those Things Which a Man of God Spake by the Spirit to Eli the Priest, Signifying that the Priesthood Which Had Been Appointed According to Aaron Was to Be Taken Away

What then does he say who comes to worship the priest of God, even the Priest who is God? “Put me into one part of Thy priesthood, to eat bread.” I do not wish to be set in the honor of my fathers, which is none; put me in a part of Thy priesthood. For “I have chosen to be mean in Thine house;” I desire to be a member, no matter what, or how small, of Thy priesthood. By the priesthood he here means the people itself, of which He is the Priest who is the Mediator between God and men, the man Christ Jesus. This people the Apostle Peter calls “a holy people, a royal priesthood.” But some have translated, “Of Thy sacrifice,” not “Of Thy priesthood,” which no less signifies the same Christian people. …

St Augustine City of God, Of Those Who Promise Impunity from All Sins Even to Heretics, Through Virtue of Their Participation of the Body of Christ

So, too, there are others who promise this deliverance from eternal punishment, not, indeed, to all men, but only to those who have been washed in Christian baptism, and who become partakers of the body of Christ, no matter how they have lived, or what heresy or impiety they have fallen into. They ground this opinion on the saying of Jesus, “This is the bread which cometh down from heaven, that if any man eat thereof, he shall not die. I am the living bread which came down from heaven. If a man eat of this bread, he shall live for ever.” Therefore, say they, it follows that these persons must be delivered from death eternal, and at one time or other be introduced to everlasting life.

St Augustine City of God, Whether Those Who Received Heretical Baptism, and Have Afterwards Fallen Away to Wickedness of Life; Or Those Who Have Received Catholic Baptism, But Have Afterwards Passed Over to Heresy and Schism; Or Those Who Have Remained in the Catholic Church in Which They Were Baptized, But Have Continued to Live Immorally, May Hope Through the Virtue of the Sacraments for the Remission of Eternal Punishment

And therefore we may reasonably inquire how we are to understand these words of the Lord Jesus: “This is the bread which cometh down from heaven, that a man may eat thereof, and not die. I am the living bread which came down from heaven. If any man eat of this bread, he shall live for ever.” And those, indeed, whom we are now answering, are refuted in their interpretation of this passage by those whom we are shortly to answer, and who do not promise this deliverance to all who have received the sacraments of baptism and the Lord’s body, but only to the catholics, however wickedly they live; for these, say they, have eaten the Lord’s body not only sacramentally, but really, being constituted members of His body, of which the apostle says, “We being many are one bread, one body.” He then who is in the unity of Christ’s body (that is to say, in the Christian membership), of which body the f …

St Augustine On Christian Doctrine, The Same Word Does Not Always Signify the Same Thing

36. Now the rule in regard to this variation has two forms. For things that signify now one thing and now another, signify either things that are contrary, or things that are only different. They signify contraries, for example, when they are used metaphorically at one time in a good sense, at another in a bad, as in the case of the leaven mentioned above. Another example of the same is that a lion stands for Christ in the place where it is said, “The lion of the tribe of Judah hath prevailed;” and again, stands for the devil where it is written, “Your adversary the devil, as a roaring lion, walketh about seeking whom he may devour.” In the same way the serpent is used in a good sense, “Be wise as serpents;” and again, in a bad sense, “The serpent beguiled Eve through his subtilty.” Bread is used in a good sense, “I am the living bread which came down from heaven;” in a bad, “Bread eaten …

St Augustine On Baptism, Against the Donatists, Chapter 50

Chapter 50. 98. It is indeed worth while to consider the whole of the passage in the aforesaid letter to Magnus, which he has put together as follows: "Not dwelling," he says, "in the house of God, that is to say, in the Church of Christ, in which none dwell save those that are of one heart and of one mind, as the Holy Spirit says in the Psalms, speaking of ‘God that maketh men to be of one mind in an house.’ Finally, the very sacrifices of the Lord declare that Christians are united among themselves by a firm and inseparable love for one another. …

30 more passages of the Fathers cite this verse. The Motif Searcher in the palace lists them all.

The Catechism cites this verse