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Numbers 21:6

Wherefore the Lord sent among the people fiery serpents, which bit them and killed many of them.

Challoner: Fiery serpentsThey are so called, because they that were bitten by them were burnt with a violent heat.
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The verse in its languages

Vulgate (Clementine)
Quam ob rem misit Dominus in populum ignitos serpentes, ad quorum plagas et mortes plurimorum,
Septuagint (Swete)
καὶ ἀπέστειλεν Κύριος εἰς τὸν λαὸν τοὺς ὄφεις τοὺς θανατοῦντας, καὶ ἔδακνον τὸν λαόν· καὶ ἀπέθανεν λαὸς πολὺς τῶν υἱῶν Ἰσραήλ.
Hebrew (WLC)
וַיְשַׁלַּ֨ח יְהוָ֜ה בָּעָ֗ם אֵ֚ת הַנְּחָשִׁ֣ים הַשְּׂרָפִ֔ים וַֽיְנַשְּׁכ֖וּ אֶת הָעָ֑ם וַיָּ֥מָת עַם רָ֖ב מִיִּשְׂרָאֵֽל

Haydock's commentary

Fiery serpents. They are so called, because they that were bitten by them were burnt with a violent heat. (Challoner)

Hence they are called seraphim, by which name an order of angels is known. The Egyptians adored a serpent which they called serapis, at Rome; and they represented their god serapis, with a serpent entwining a monstrous figure, composed of a lion, a dog, and a wolf. (Macrob. Saturn i. 20.) The seraph was a winged serpent, Isaias xiv. 29. xxx. 6. Such often infested Egypt, in spring, coming from Arabia, unless they were intercepted by the ibis. Their wings resembled those of bats. (Herodotus, ii. 76.; Mela, &c.) God probably sent some of this description into the camp of the Israelites. (Calmet)

Some call them prœster, (Pliny, [Natural History?] xxiv. 13,) from their burning; others the hydra, or, when out of water, the chershydra, the venom of which is most dangerous. The Septuagint style them simply, "the destroying, or deadly serpents." See Bochart, T. ii. B. iii. 13.; Deuteronomy viii. 15.; Wisdom xvi. 5, 10.) (Haydock)

From Haydock's Catholic Bible Commentary, 1859, in the transcription made by Todd Easton and kept online by John Paul Wohlschied at johnblood.gitlab.io/haydock.

The Fathers on this verse

Tertullian Appendix: Against All Heresies, Ophites, Cainites, Sethites

To these are added those heretics likewise who are called Ophites : for they magnify the serpent to such a degree, that they prefer him even to Christ Himself; for it was he, they say, who gave us the origin of the knowledge of good and of evil. His power and majesty (they say) Moses perceiving, set up the brazen serpent; and whoever gazed upon him obtained health. Christ Himself (they say further) in His gospel imitates Moses’ serpent’s sacred power, in saying: “And as Moses upreared the serpent in the desert, so it behoveth the Son of man to be upreared.” Him they introduce to bless their eucharistic (elements). Now the whole parade and doctrine of this error flowed from the following source. They say that from the supreme primary Æon whom men speak of there emanated several other inferior Æons. To all these, however, there opposed himself an Æon who name is Ialdabaoth . …

St Augustine A Treatise on the Merits and Forgiveness of Sins, and on the Baptism of Infants, The Serpent Lifted Up in the Wilderness Prefigured Christ Suspended on the Cross; Even Infants Themselves Poisoned by the Serpent’s Bite

And since this great and wonderful dignity can only be attained by the remission of sins, He goes on to say, “And as Moses lifted up the serpent in the wilderness, even so must the Son of man be lifted up; that whosoever believeth in Him should not perish, but have eternal life.” We know what at that time happened in the wilderness. Many were dying of the bite of serpents: the people then confessed their sins, and, through Moses, besought the Lord to take away from them this poison; accordingly, Moses, at the Lord’s command, lifted up a brazen serpent in the wilderness, and admonished the people that every one who had been serpent-bitten should look upon the uplifted figure. When they did so they were immediately healed. …

St Augustine Lectures or Tractates on the Gospel According to St. John, Chapter III. 6-21

11. He endured death, then; but death He hanged on the cross, and mortal men are delivered from death. The Lord calls to mind a great matter, which was done in a figure with them of old: “And as Moses,” saith He, “lifted up the serpent in the wilderness, so must the Son of man be lifted up; that every one who believeth on Him may not perish, but have everlasting life.” A great mystery is here, as they who read know. Again, let them hear, as well they who have not read as they who have forgotten what perhaps they had heard or read. The people Israel were fallen helplessly in the wilderness by the bite of serpents; they suffered a great calamity by many deaths: for it was the stroke of God correcting and scourging them that He might instruct them. …

The Catechism cites this verse