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Ephesians 5:32

This is a great sacrament; but I speak in Christ and in the church.

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The verse in its languages

Vulgate (Clementine)
Sacramentum hoc magnum est, ego autem dico in Christo et in Ecclesia.
Greek New Testament (SBLGNT)
τὸ μυστήριον τοῦτο μέγα ἐστίν, ἐγὼ δὲ λέγω εἰς Χριστὸν καὶ εἰς τὴν ἐκκλησίαν.

Haydock's commentary

This....sacrament, (or mystery)....in Christ, and in the Church. This sacrament, in construction, must be referred to what immediately went before, i.e. to the conjunction of marriage betwixt man and wife; and this is called a great sacrament, or mystery, as representing the union or spiritual nuptials of Christ with his spouse, the Church. (Witham)

From Haydock's Catholic Bible Commentary, 1859, in the transcription made by Todd Easton and kept online by John Paul Wohlschied at johnblood.gitlab.io/haydock.

The Fathers on this verse

St Irenaeus Against Heresies: Book I, Chapter VIII. How the Valentinians

4. Moreover, that Achamoth wandered beyond the Pleroma, and received form from Christ, and was sought after by the Saviour, they declare that He indicated when He said, that He had come after that sheep which was gone astray. For they explain the wandering sheep to mean their mother, by whom they represent the Church as having been sown. The wandering itself denotes her stay outside of the Pleroma in a state of varied passion, from which they maintain that matter derived its origin. The woman, again, who sweeps the house and finds the piece of money, they declare to denote the Sophia above, who, having lost her enthymesis, afterwards recovered it, on all things being purified by the advent of the Saviour. Wherefore this substance also, according to them, was reinstated in Pleroma. …

Tertullian A Treatise on the Soul, Spirit--A Term Expressive of an Operation of the Soul, Not of Its Nature. To Be Carefully Distinguished from the Spirit of God

But the nature of my present inquiry obliges me to call the soul spirit or breath, because to breathe is ascribed to another substance. We, however, claim this (operation) for the soul, which we acknowledge to be an indivisible simple substance, and therefore we must call it spirit in a definitive sense, not because of its condition, but of its action; not in respect of its nature, but of its operation; because it respires , and not because it is spirit in any especial sense. For to blow or breathe is to respire. So that we are driven to describe, by (the term which indicates this respiration, that is to say) spirit, the soul which we hold to be, by the propriety of its action, breath. Moreover, we properly and especially insist on calling it breath (or spirit), in opposition to Hermogenes, who derives the soul from matter instead of from the afflatus or breath of God. …

Tertullian A Treatise on the Soul, As Free-Will Actuates an Individual So May His Character Change

Now, if the soul possessed this uniform and simple nature from the beginning in Adam, previous to so many mental dispositions (being developed out of it), it is not rendered multiform by such various development, nor by the triple form predicated of it in “ the Valentinian trinity ” (that we may still keep the condemnation of that heresy in view), for not even this nature is discoverable in Adam. What had he that was spiritual? Is it because he prophetically declared “the great mystery of Christ and the church?” “This is bone of my bone, and flesh of my flesh: she shall be called Woman. Therefore shall a man leave his father and mother, and he shall cleave unto his wife; and they two shall be one flesh.” But this (gift of prophecy) only came on him afterwards, when God infused into him the ecstasy, or spiritual quality, in which prophecy consists. …

Tertullian The Five Books Against Marcion, Sundry Features of the Prophetic Style: Principles of Its Interpretation

These preliminary remarks I have ventured to make at this first step of the discussion and while the conflict is, as it were, from a distance. But inasmuch as I shall now from this point have to grapple with my opponent on a distinct issue and in close combat, I perceive that I must advance even here some lines, at which the battle will have to be delivered; they are the Scriptures of the Creator. For as I shall have to prove that Christ was from the Creator, according to these (Scriptures), which were afterwards accomplished in the Creator’s Christ, I find it necessary to set forth the form and, so to speak, the nature of the Scriptures themselves, that they may not distract the reader’s attention by being called into controversy at the moment of their application to subjects of discussion, and by their proof being confounded with the proof of the subjects themselves. …

Tertullian The Five Books Against Marcion, Another Foolish Erasure of Marcion's Exposed. Certain Figurative Expressions of the Apostle, Suggested by the Language of the Old Testament. Collation of Many Passages of This Epistle, with Precepts and Statements in the Pentateuch, the Psalms, and the Prophets. All Alike Teach Us the Will and Purpose of the Creator

As our heretic is so fond of his pruning-knife, I do not wonder when syllables are expunged by his hand, seeing that entire pages are usually the matter on which he practises his effacing process. The apostle declares that to himself, “less than the least of all saints, was the grace given” of enlightening all men as to “what was the fellowship of the mystery, which during the ages had been hid in God, who created all things.” The heretic erased the preposition in , and made the clause run thus: (“what is the fellowship of the mystery) which hath for ages been hidden from the God who created all things.” The falsification, however, is flagrantly absurd. …

St Cyprian The Epistles of Cyprian, Epistle XLVIII

1. Cyprian to Cornelius his brother, greeting. You have acted, dearest brother, both with diligence and love, in sending us in haste Nicephorus the acolyte, who both told us the glorious gladness concerning the return of the confessors, and most fully instructed us against the new and mischievous devices of Novatian and Novatus for attacking the Church of Christ. For whereas on the day before, that mischievous faction of heretical wickedness had arrived here, itself already lost and ready to ruin others who should join it, on the day after, Nicephorus arrived with your letter. …

St Methodius The Banquet of the Ten Virgins; or Concerning Chastity, Chapter I

Chapter I. Passages of Holy Scripture Compared.

Origen Origen's Commentary on Matthew, Chapter XVII

But since the Apostle understands the words, “ And they twain shall be one flesh, ” of Christ and the church, we must say that Christ keeping the saying, “What God hath joined together let not man put asunder,” did not put away His former wife, so to speak, that is, the former synagogue, for any other cause than that that wife committed fornication, being made an adulteress by the evil one, and along with him plotted against her husband and slew Him, saying, “Away with such a fellow from the earth, crucify Him, crucify Him.” It was she therefore who herself revolted, rather than her husband who put her away and dismissed her; wherefore, reproaching her for falling away from him, it says in Isaiah, “Of what kind is the bill of your mother’s divorcement, with which I sent her away?” And He who at the beginning created Him “who is in the form of God” after the image, made Him male, and the …

St Augustine Reply to Faustus the Manichæan, Faustus denies that the prophets predicted Christ. Augustin proves such prediction from the New Testament, and expounds at length the principal types of Christ in the Old Testament

8. In the creation God finished His works in six days, and rested on the seventh. The history of the world contains six periods marked by the dealings of God with men. The first period is from Adam to Noah; the second, from Noah to Abraham; the third, from Abraham to David; the fourth, from David to the captivity in Babylon; the fifth, from the captivity to the advent of lowliness of our Lord Jesus Christ; the sixth is now in progress, and will end in the coming of the exalted Saviour to judgment. What answers to the seventh day is the rest of the saints, not in this life, but in another, where the rich man saw Lazarus at rest while he was tormented in hell; where there is no evening, because there is no decay. …

St Augustine Reply to Faustus the Manichæan, Faustus states his objections to the morality of the law and the prophets, and Augustin seeks by the application of the type and the allegory to explain away the moral difficulties of the Old Testament

38. But a pleasure which all must feel is obtained from this narrative so faithfully recorded in the Holy Scriptures, when we examine into the prophetic character of the action, and knock with pious faith and diligence at the door of the mystery, that the Lord may open, and show us who was prefigured in the ancient personage, and whose wife this is, who, while in a foreign land and among strangers, is not allowed to be stained or defiled, that she may be brought to her own husband without spot or wrinkle. Thus we find that the righteous life of the Church is for the glory of Christ, that her beauty may bring honor to her husband, as Abraham was honored on account of the beauty of Sara among the inhabitants of that foreign land. …

St Augustine Our Lord’s Sermon on the Mount, Chapter XII

42. It is usual, therefore, to ask what He means, when He says: “But ye, when ye fast, anoint your head, and wash your faces, that ye appear not unto men to fast.” For it would not be right in any one to teach (although we may wash our face according to daily custom) that we ought also to have our heads anointed when we fast. If, then, all admit this to be most unseemly, we must understand this precept with respect to anointing the head and washing the face as referring to the inner man. Hence, to anoint the head refers to joy; to wash the face, on the other hand, refers to purity: and therefore that man anoints his head who rejoices inwardly in his mind and reason. For we rightly understand that as being the head which has the pre-eminence in the soul, and by which it is evident that the other parts of man are ruled and governed. …

St Augustine Sermons on Selected Lessons of the New Testament, On the words of the Gospel, John v. 39, ‘Ye search the Scriptures, because ye think that in them ye have eternal life,’ etc. Against the Donatists

4. But as I have said, let us leave these, and attend rather to these our brethren, with whom we have to do. For Christ is the Head of the Body. The Head is in Heaven, the Body is on earth; the Head is the Lord, the Body His Church. But ye remember it is said, “They shall be two in one flesh.” “This is a great mystery,” says the Apostle, “but I speak in Christ and in the Church.” If then they are two in one flesh, they are two in one voice. Our Head the Lord Christ spake to the Jews these things which we heard, when the Gospel was being read, The Head to His enemies; let the Body too, that is, the Church, speak to its enemies. Ye know to whom it should speak. What has it to say? It is not of myself that I have said, that the voice is one; because the flesh is one, the voice is one. Let us then say this to them; I am speaking with the voice of the Church. …

15 more passages of the Fathers cite this verse. The Motif Searcher in the palace lists them all.

The Fathers are given as they wrote. Where a passage lays the Passion on the Jewish people, the Church teaches that it cannot be charged against all the Jews then living, nor against the Jews of today, and that all sinners were its authors (CCC 597, 598).

The Catechism cites this verse