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Genesis 2:24

Wherefore a man shall leave father and mother, and shall cleave to his wife: and they shall be two in one flesh.

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The verse in its languages

Vulgate (Clementine)
Quam ob rem relinquet homo patrem suum, et matrem, et adhærebit uxori suæ : et erunt duo in carne una.
Septuagint (Swete)
ἕνεκεν τούτου καταλείψει ἄνθρωπος τὸν πατέρα αὐτοῦ καὶ τὴν μητέρα αὐτοῦ, καὶ ⸂⸆⸃ προσκολληθήσεται τῇ γυναικὶ αὐτοῦ· καὶ ἔσονται οἱ δύο εἰς σάρκα μίαν.
Hebrew (WLC)
עַל כֵּן֙ יַֽעֲזָב אִ֔ישׁ אֶת אָבִ֖יו וְאֶת אִמּ֑וֹ וְדָבַ֣ק בְּאִשְׁתּ֔וֹ וְהָי֖וּ לְבָשָׂ֥ר אֶחָֽד

Haydock's commentary

One flesh, connected by the closest ties of union, producing children, the blood of both. St. Paul, Ephesians v. 23, discloses to us the mystery of Christ's union with his church for ever, prefigured by this indissoluble marriage of our first parents. (Calmet)

From Haydock's Catholic Bible Commentary, 1859, in the transcription made by Todd Easton and kept online by John Paul Wohlschied at johnblood.gitlab.io/haydock.

The Fathers on this verse

Tertullian A Treatise on the Soul, Spirit--A Term Expressive of an Operation of the Soul, Not of Its Nature. To Be Carefully Distinguished from the Spirit of God

But the nature of my present inquiry obliges me to call the soul spirit or breath, because to breathe is ascribed to another substance. We, however, claim this (operation) for the soul, which we acknowledge to be an indivisible simple substance, and therefore we must call it spirit in a definitive sense, not because of its condition, but of its action; not in respect of its nature, but of its operation; because it respires , and not because it is spirit in any especial sense. For to blow or breathe is to respire. So that we are driven to describe, by (the term which indicates this respiration, that is to say) spirit, the soul which we hold to be, by the propriety of its action, breath. Moreover, we properly and especially insist on calling it breath (or spirit), in opposition to Hermogenes, who derives the soul from matter instead of from the afflatus or breath of God. …

Tertullian A Treatise on the Soul, As Free-Will Actuates an Individual So May His Character Change

Now, if the soul possessed this uniform and simple nature from the beginning in Adam, previous to so many mental dispositions (being developed out of it), it is not rendered multiform by such various development, nor by the triple form predicated of it in “ the Valentinian trinity ” (that we may still keep the condemnation of that heresy in view), for not even this nature is discoverable in Adam. What had he that was spiritual? Is it because he prophetically declared “the great mystery of Christ and the church?” “This is bone of my bone, and flesh of my flesh: she shall be called Woman. Therefore shall a man leave his father and mother, and he shall cleave unto his wife; and they two shall be one flesh.” But this (gift of prophecy) only came on him afterwards, when God infused into him the ecstasy, or spiritual quality, in which prophecy consists. …

Tertullian To His Wife, Chapter VIII

What am I to fasten on as the cause of this madness, except the weakness of faith, ever prone to the concupiscences of worldly joys? which, indeed, is chiefly found among the wealthier; for the more any is rich, and inflated with the name of “matron,” the more capacious house does she require for her burdens, as it were a field wherein ambition may run its course. To such the churches look paltry. A rich man is a difficult thing (to find) in the house of God; and if such an one is (found there), difficult (is it to find such) unmarried. What, then, are they to do? Whence but from the devil are they to seek a husband apt for maintaining their sedan, and their mules, and their hair-curlers of outlandish stature? A Christian, even although rich, would perhaps not afford (all) these. Set before yourself, I beg of you, the examples of Gentiles. …

Tertullian On Exhortation to Chastity, Chapter V

For the laying down of the law of once marrying, the very origin of the human race is our authority; witnessing as it emphatically does what God constituted in the beginning for a type to be examined with care by posterity. For when He had moulded man, and had foreseen that a peer was necessary for him, He borrowed from his ribs one, and fashioned for him one woman; whereas, of course, neither the Artificer nor the material would have been insufficient (for the creation of more). There were more ribs in Adam, and hands that knew no weariness in God; but not more wives in the eye of God. And accordingly the man of God, Adam, and the woman of God, Eve, discharging mutually (the duties of) one marriage, sanctioned for mankind a type by (the considerations of) the authoritative precedent of their origin and the primal will of God. …

Origen Origen De Principiis, Chapter VI

3. The Only-begotten of God, therefore, through whom, as the previous course of the discussion has shown, all things were made, visible and invisible, according to the view of Scripture, both made all things, and loves what He made. For since He is Himself the invisible image of the invisible God, He conveyed invisibly a share in Himself to all His rational creatures, so that each one obtained a part of Him exactly proportioned to the amount of affection with which he regarded Him. …

St Methodius The Banquet of the Ten Virgins; or Concerning Chastity, Chapter I

Chapter I. Passages of Holy Scripture Compared.

St Methodius The Banquet of the Ten Virgins; or Concerning Chastity, Chapter I

You seem to me, O Theophila, to excel all in action and in speech, and to be second to none in wisdom. For there is no one who will find fault with your discourse, however contentious and contradictory he may be. Yet, while everything else seems rightly spoken, one thing, my friend, distresses and troubles me, considering that that wise and most spiritual man, I mean Paul, would not vainly refer to Christ and the Church the union of the first man and woman, if the Scripture meant nothing higher than what is conveyed by the mere words and the history; for if we are to take the Scripture as a bare representation wholly referring to the union of man and woman, for what reason should the apostle, calling these things to remembrance, and guiding us, as I opine, into the way of the Spirit, allegorize the history of Adam and Eve as having a reference to Christ and the Church? For the passage in …

St Methodius The Banquet of the Ten Virgins; or Concerning Chastity, Chapter X

Now Paul, when summoning all persons to sanctification and purity, in this way referred that which had been spoken concerning the first man and Eve in a secondary sense to Christ and the Church, in order to silence the ignorant, now deprived of all excuse. For men who are incontinent in consequence of the uncontrolled impulses of sensuality in them, dare to force the Scriptures beyond their true meaning, so as to twist into a defence of their incontinence the saying, “Increase and multiply;” and the other, “Therefore shall a man leave his father and his mother;” and they are not ashamed to run counter to the Spirit, but, as though born for this purpose, they kindle up the smouldering and lurking passion, fanning and provoking it; and therefore he, cutting off very sharply these dishonest follies and invented excuses, and having arrived at the subject of instructing them how men should be …

St Methodius From the Discourse on the Resurrection, Part I

II. Now the question has already been raised, and answered, that the “coats of skins” are not bodies. Nevertheless, let us speak of it again, for it is not enough to have mentioned it once. Before the preparation of these coats of skins, the first man himself acknowledges that he has both bones and flesh; for when he saw the woman brought to him: “This is now,” he cried, “bone of my bone and flesh of my flesh.” And again: She shall be called Woman, because she was taken out of man. For this cause shall a man leave his father and mother, and shall be joined unto his wife, and they two shall be one flesh.” For I cannot endure the trifling of some who shamelessly do violence to Scripture, in order that their opinion, that the resurrection is without flesh, may find support; supposing rational bones and flesh, and in different ways changing it backwards and forwards by allegorizing. …

The Apostolic Constitutions Book III, Sec. I. Concerning Widows

II. But let not the younger widows be placed in the order of widows, lest, under pretence of inability to contain in the flower of their age, they come to a second marriage, and become subject to imputation. But let them be assisted and supported, that so they may not, under pretence of being deserted, come to a second marriage, and so be ensnared in an unseemly imputation. For you ought to know this, that once marrying according to the law is righteous, as being according to the will of God; but second marriages, after the promise, are wicked, not on account of the marriage itself, but because of the falsehood. Third marriages are indications of incontinency. But such marriages as are beyond the third are manifest fornication, and unquestionable uncleanness. …

The Apostolic Constitutions Book VII. Concerning the Christian Life, and the Eucharist, and the Initiation into Christ, Sec. I. On the Two Ways, The Way of Life and the Way of Death

II . The first way, therefore, is that of life; and is this, which the law also does appoint: “To love the Lord God with all thy mind, and with all thy soul, who is the one and only God, besides whom there is no other;” “and thy neighbour as thyself.” And whatsoever thou wouldest not should be done to thee, that do not thou to another.” “Bless them that curse you; pray for them that despitefully use you.” “Love your enemies; for what thanks is it if ye love those that love you? for even the Gentiles do the same.” “But do ye love those that hate you, and ye shall have no enemy.” For says He, “Thou shalt not hate any man; no, not an Egyptian, nor an Edomite;” for they are all the workmanship of God. Avoid not the persons, but the sentiments, of the wicked. …

Origen Origen's Commentary on Matthew, Chapter XVI

After this it is written that “ there came unto Him the Pharisees tempting Him and saying, Is it lawful for a man to wife for every cause? ” Mark, also, has written to the like effect. Accordingly, of those who came to Jesus and inquired of Him, there were some who put questions to tempt Him; and if our Saviour so transcendent was tempted, which of His disciples who is ordained to teach need be vexed, when he is tempted by some who inquire, not from the love of learning, but from the wish to tempt? And you might find many passages, if you brought them together, in which the Pharisees tempted our Jesus, and others, different from them, as a certain lawyer, and perhaps also a scribe, that by bringing together what is said about those who tempted Him, you might find by investigation what is useful for this kind of inquiries. …

33 more passages of the Fathers cite this verse. The Motif Searcher in the palace lists them all.

The Catechism cites this verse