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Genesis 4:24

Sevenfold vengeance shall be taken for Cain: but for Lamech seventy times sevenfold.

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The verse in its languages

Vulgate (Clementine)
Septuplum ultio dabitur de Cain : de Lamech vero septuagies septies.
Septuagint (Swete)
ὅτι ἑπτάκις ἐκδεδίκηται ἐκ Κάιν, ἐκ δὲ Λάμεχ ἑβδομηκοντάκις ἑπτά.
Hebrew (WLC)
כִּ֥י שִׁבְעָתַ֖יִם יֻקַּם קָ֑יִן וְלֶ֖מֶךְ שִׁבְעִ֥ים וְשִׁבְעָֽה

Haydock's commentary

Seventy times. A similar expression occurs, Matthew xviii. 22, to denote a great but indefinite number. God had promised to revenge the murder of Cain seven fold, though he had sinned voluntarily; so Lamech hopes that, as he had acted by mistake, and blinded by passion, in striking the stripling, the son of Tubalcain, he would deserve to be protected still more from falling a prey to the fury of any other. But many reject this tradition as fabulous, unknown to Philo, Josephus, &c. Moses no where mentions the death of Cain. Some, therefore, understand this passage with an interrogation; as if, to convince his wives that his sin was not so enormous as was supposed, he should say, Do not think of leaving me. What! have I killed a young man, as Cain did Abel, and still he is suffered to live unmolested; or have I beaten any one so that I should be punished? Onkelos, in effect, puts a negation to the same purport, "I have not killed, &c.:" (Calmet) others understand this passage, as if Lamech considered his crimes as much more grievous than even those of Cain. (Tirinus)

From Haydock's Catholic Bible Commentary, 1859, in the transcription made by Todd Easton and kept online by John Paul Wohlschied at johnblood.gitlab.io/haydock.

The Fathers on this verse

Tertullian On Prayer, The Sixth Clause

It was suitable that, after contemplating the liberality of God, we should likewise address His clemency. For what will aliments profit us, if we are really consigned to them, as it were a bull destined for a victim? The Lord knew Himself to be the only guiltless One, and so He teaches that we beg “to have our debts remitted us.” A petition for pardon is a full confession; because he who begs for pardon fully admits his guilt. Thus, too, penitence is demonstrated acceptable to God who desires it rather than the death of the sinner. Moreover, debt is, in the Scriptures, a figure of guilt ; because it is equally due to the sentence of judgment, and is exacted by it: nor does it evade the justice of exaction, unless the exaction be remitted, just as the lord remitted to that slave in the parable his debt; for hither does the scope of the whole parable tend. …

St John Chrysostom The Homilies of St. John Chrysostom, Matthew XXIII. 29, 30

Heardest thou not Lamech saying, “Of Lamech vengeance shall be taken seventy times sevenfold;”that is, “I am deserving of more punishment than Cain.” Why could this be? Yet he did not slay his brother; but because not even by his example was he brought to a better mind. And this is what God saith elsewhere, “Requiting the sins of fathers upon children for the third and fourth generation of them that hate me.” Not as though one were to suffer punishment for the crimes committed by others, but inasmuch as they who, after many sin and have been punished, yet have not grown better, but have committed the same offenses, are justly worthy to suffer their punishments also.

St Gregory Nazianzen The Second Theological Oration

XVIII. Thus Enos “hoped to call upon the Name of the Lord.” Hope was that for which he is commended; and that, not that he should know God, but that he should call upon him. And Enoch was translated, but it is not yet clear whether it was because he already comprehended the Divine Nature, or in order that he might comprehend it. And Noah’s glory was that he was pleasing to God; he who was entrusted with the saving of the whole world from the waters, or rather of the Seeds of the world, escaped the Deluge in a small Ark. And Abraham, great Patriarch though he was, was justified by faith, and offered a strange victim, the type of the Great Sacrifice. Yet he saw not God as God, but gave Him food as a man. He was approved because he worshipped as far as he comprehended. …

St Gregory Nazianzen On Pentecost

III. As to the honour paid to Seven there are many testimonies, but we will be content with a few out of the many. For instance, seven precious spirits are named; for I think Isaiah loves to call the activities of the Spirit spirits; and the Oracles of the Lord are purified seven times according to David, and the just is delivered from six troubles and in the seventh is not smitten. But the sinner is pardoned not seven times, but seventy times seven. And we may see it by the contrary also (for the punishment of wickedness is to be praised), Cain being avenged seven times, that is, punishment being exacted from him for his fratricide, and Lamech seventy times seven, because he was a murderer after the law and the condemnation. …

St Basil The Letters, To Optimus the bishop

5. Your next question is of a kindred character, concerning the words of Lamech to his wives; “I have slain a man to my wounding, and a young man to my hurt: if Cain shall be avenged sevenfold, truly Lamech seventy and sevenfold.” Some suppose that Cain was slain by Lamech, and that he survived to this generation that he might suffer a longer punishment. But this is not the case. Lamech evidently committed two murders, from what he says himself, “I have slain a man and a young man,” the man to his wounding, and the young man to his hurt. There is a difference between wounding and hurt. And there is a difference between a man and a young man. “If Cain shall be avenged sevenfold, truly Lamech seventy and sevenfold.” It is right that I should undergo four hundred and ninety punishments, if God’s judgment on Cain was just, that his punishments should be seven. …