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Isaias 53:4

Surely he hath borne our infirmities and carried our sorrows: and we have thought him as it were a leper, and as one struck by God and afflicted.

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The verse in its languages

Vulgate (Clementine)
Vere languores nostros ipse tulit, et dolores nostros ipse portavit ; et nos putavimus eum quasi leprosum, et percussum a Deo, et humiliatum.
Septuagint (Swete)
οὗτος τὰς ἁμαρτίας ἡμῶν φέρει καὶ περὶ ἡμῶν ὀδυνᾶται, καὶ ἡμεῖς ἐλογισάμεθα αὐτὸν εἶναι ἐν πόνῳ καὶ ἐν πληγῇ καὶ ἐν κακώσει.
Hebrew (WLC)
אָכֵ֤ן חֳלָיֵ֨נוּ֙ ה֣וּא נָשָׂ֔א וּמַכְאֹבֵ֖ינוּ סְבָלָ֑ם וַאֲנַ֣חְנוּ חֲשַׁבְנֻ֔הוּ נָג֛וּעַ מֻכֵּ֥ה אֱלֹהִ֖ים וּמְעֻנֶּֽה

Haydock's commentary

Sorrows. Healing them by his own afflictions, Matthew viii. 15. Sickness is an effect of sin, which Jesus came to destroy, 1 Peter ii. 24

Leper, who was bound to have his face covered, ver. 3., and Leviticus xiii. 45.

God. Payva (Def. Trin. iv.) assures us that many Jews were converted by the perusal of this chapter, and particularly of this verse, which may be rendered "as a God wounded and afflicted." (Calmet)

From Haydock's Catholic Bible Commentary, 1859, in the transcription made by Todd Easton and kept online by John Paul Wohlschied at johnblood.gitlab.io/haydock.

The Fathers on this verse

St Justin Martyr The First Apology, Chapter L. His humiliation

But that, having become man for our sakes, He endured to suffer and to be dishonoured, and that He shall come again with glory, hear the prophecies which relate to this; they are these: “Because they delivered His soul unto death, and He was numbered with the transgressors, He has borne the sin of many, and shall make intercession for the transgressors. For, behold, My Servant shall deal prudently, and shall be exalted, and shall be greatly extolled. As many were astonished at Thee, so marred shall Thy form be before men, and so hidden from them Thy glory; so shall many nations wonder, and the kings shall shut their mouths at Him. For they to whom it was not told concerning Him, and they who have not heard, shall understand. O Lord, who hath believed our report? and to whom is the arm of the Lord revealed? We have declared before Him as a child, as a root in a dry ground. …

St Irenaeus Against Heresies: Book IV, Chapter XXXIII. Whosoever confesses

11. For some of them, beholding Him in glory, saw His glorious life ( conversationem ) at the Father’s right hand; others beheld Him coming on the clouds as the Son of man; and those who declared regarding Him, “They shall look on Him whom they have pierced,” indicated His [second] advent, concerning which He Himself says, “Thinkest thou that when the Son of man cometh, He shall find faith on the earth?” Paul also refers to this event when he says, “If, however, it is a righteous thing with God to recompense tribulation to them that trouble you, and to you that are troubled rest with us, at the revelation of the Lord Jesus from heaven, with His mighty angels, and in a flame of fire.” Others again, speaking of Him as a judge, and [referring], as if it were a burning furnace, [to] the day of the Lord, who “gathers the wheat into His barn, but will burn up the chaff with unquenchable fire,” …

Tertullian The Five Books Against Marcion, Prophecy Sets Forth Two Different Conditions of Christ, One Lowly, the Other Majestic. This Fact Points to Two Advents of Christ

Our heretic will now have the fullest opportunity of learning the clue of his errors along with the Jew himself, from whom he has borrowed his guidance in this discussion. Since, however, the blind leads the blind, they fall into the ditch together. We affirm that, as there are two conditions demonstrated by the prophets to belong to Christ, so these presignified the same number of advents; one, and that the first, was to be in lowliness, when He had to be led as a sheep to be slain as a victim, and to be as a lamb dumb before the shearer, not opening His mouth, and not fair to look upon. …

Tertullian The Five Books Against Marcion, Prophecies in Isaiah and the Psalms Respecting Christ's Humiliation

Let us compare with Scripture the rest of His dispensation. Whatever that poor despised body may be, because it was an object of touch and sight, it shall be my Christ, be He inglorious, be He ignoble, be He dishonoured; for such was it announced that He should be, both in bodily condition and aspect. Isaiah comes to our help again: “We have announced (His way) before Him,” says he; “He is like a servant, like a root in a dry ground; He hath no form nor comeliness; we saw Him, and He had neither form nor beauty; but His form was despised, marred above all men.” Similarly the Father addressed the Son just before: “Inasmuch as many will be astonished at Thee, so also will Thy beauty be without glory from men.” For although, in David’s words, He is fairer than the children of men,” yet it is in that figurative state of spiritual grace, when He is girded with the sword of the Spirit, which i …

Tertullian The Five Books Against Marcion, Other Proofs from the Same Chapter, that Jesus, Who Preached at Nazareth, and Was Acknowledged by Certain Demons as Christ the Son of God, Was the Creator's Christ. As Occasion Offers, the Docetic Errors of Marcion are Exposed

is even a sentence worthy of a place in the world’s wisdom. In short, He did himself touch others, upon whom He laid His hands, which were capable of being felt, and conferred the blessings of healing, which were not less true, not less unimaginary, than were the hands wherewith He bestowed them. He was therefore the very Christ of Isaiah, the healer of our sicknesses. “Surely,” says he, “He hath borne our griefs and carried our sorrows.” Now the Greeks are accustomed to use for carry a word which also signifies to take away . A general promise is enough for me in passing. Whatever were the cures which Jesus effected, He is mine. We will come, however, to the kinds of cures. To liberate men, then, from evil spirits, is a cure of sickness. …

St Hippolytus Treatise on Christ and Antichrist

44. For as two advents of our Lord and Saviour are indicated in the Scriptures, the one being His first advent in the flesh, which took place without honour by reason of His being set at nought, as Isaiah spake of Him aforetime, saying, “We saw Him, and He had no form nor comeliness, but His form was despised (and) rejected (lit. = deficient) above all men; a man smitten and familiar with bearing infirmity, (for His face was turned away); He was despised, and esteemed not.” But His second advent is announced as glorious, when He shall come from heaven with the host of angels, and the glory of His Father, as the prophet saith, “Ye shall see the King in glory;” and, “I saw one like the Son of man coming with the clouds of heaven; and he came to the Ancient of days, and he was brought to Him. …

St Hippolytus Against the Heresy of One Noetus

18. Thus then, too, though demonstrated as God, He does not refuse the conditions proper to Him as man, since He hungers and toils and thirsts in weariness, and flees in fear, and prays in trouble. And He who as God has a sleepless nature, slumbers on a pillow. And He who for this end came into the world, begs off from the cup of suffering. And in an agony He sweats blood, and is strengthened by an angel, who Himself strengthens those who believe on Him, and taught men to despise death by His work. And He who knew what manner of man Judas was, is betrayed by Judas. And He, who formerly was honoured by him as God, is contemned by Caiaphas. And He is set at nought by Herod, who is Himself to judge the whole earth. And He is scourged by Pilate, who took upon Himself our infirmities. …

St Gregory Thaumaturgus Twelve Topics on the Faith, Topic XI

How could one say that the body of the Lord (Christ) is void of soul and understanding? For perturbation, and grief, and distress, are not the properties either of a flesh void of soul, or of a soul void of understanding; nor are they the sign of the immutable Divinity, nor the index of a mere phantasm, nor do they mark the defect of human weakness; but the Word exhibited in Himself the exercise of the affections and susceptibilities proper to us, having endued Himself with our passibility, even as it is written, that “He hath borne our griefs, and carried our sorrows.” For perturbation, and grief, and distress, are disorders of soul; and toil, and sleep, and the body’s liability to wounding, are infirmities of the flesh.

Lactantius The Divine Institutes, Chap. XVI. Of the passion of Jesus Christ; that it was foretold

Now His humility emboldened them to this deed. For when they read with what great power and glory the Son of God was about to descend from heaven, but on the other hand saw Jesus humble, peaceful, of low condition, without comeliness, they did not believe that He was the Son of God, being ignorant that two advents on His part were foretold by the prophets: the first, obscure in humility of the flesh; the other, manifest in the power of His majesty. Of the first David thus speaks in the seventy-first Psalm: “He shall descend as rain upon a fleece; and in His days shall righteousness spring forth, and abundance of peace, as long as the moon is lifted up.” For as rain, if it descends upon a fleece, cannot be perceived, because it makes no sound; so he said that Christ would come to the earth without exciting the notice of any, that He might teach righteousness and peace. …

The Apostolic Constitutions Book II. Of Bishops, Presbyters, and Deacons, Sec. IV. On the Management of the Resources Collected for the Support of the Clergy, and the Relief of the Poor

XXV . Let him use those tenths and first-fruits, which are given according to the command of God, as a man of God; as also let him dispense in a right manner the free-will offerings which are brought in on account of the poor, to the orphans, the widows, the afflicted, and strangers in distress, as having that God for the examiner of his accounts who has committed the disposition to him. Distribute to all those in want with righteousness, and yourselves use the things which belong to the Lord, but do not abuse them; eating of them, but not eating them all up by yourselves: communicate with those that are in want, and thereby show yourselves unblameable before God. …

Origen Origen's Commentary on Matthew, Chapter XXIX

“ For the Son of man shall come in the glory of His own Father with His angels. ” Now, indeed, the Son of man has not come in His glory; “for we saw Him, and He had no form nor beauty; but His form was dishonoured and defective compared with the sons of men; He was a man in affliction and toil, and acquainted with the enduring of sickness, because His face was turned away, He was dishonoured and not esteemed.” And it was necessary that He should come in such form that He might bear our sins and suffer pain for us; for it did not become Him in glory to bear our sins and suffer pain for us. …

St Augustine A Treatise on the Merits and Forgiveness of Sins, and on the Baptism of Infants, By the Sacrifices of the Old Testament, Men Were Convinced of Sins and Led to the Saviour

And yet it is perhaps better to advance a few testimonies out of the Old Testament also, which ought to have a supplementary, or rather a cumulative value. The Lord Himself, speaking by the Psalmist, says: “As for my saints which are upon earth, He hath caused all my purposes to be admired in them.” Not their merits , but “ my purposes. ” For what is theirs except that which is afterwards mentioned, “their weaknesses are multiplied,”, above the weakness that they had? Moreover, the law also entered, that the offence might abound. But why does the Psalmist immediately add: “They hastened after?” When their sorrows and infirmities multiplied (that is, when their offence abounded), they then sought the Physician more eagerly, in order that, where sin abounded, grace might much more abound. …

12 more passages of the Fathers cite this verse. The Motif Searcher in the palace lists them all.

The Fathers are given as they wrote. Where a passage lays the Passion on the Jewish people, the Church teaches that it cannot be charged against all the Jews then living, nor against the Jews of today, and that all sinners were its authors (CCC 597, 598).

The Catechism cites this verse