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Isaias 64:4

From the beginning of the world they have not heard, nor perceived with the ears: the eye hath not seen, O God, besides thee, what things thou hast prepared for them that wait for thee.

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The verse in its languages

Vulgate (Clementine)
A sæculo non audierunt, neque auribus perceperunt ; oculus non vidit, Deus, absque te, quæ præparasti exspectantibus te.
Septuagint (Swete)
ἀπὸ τοῦ αἰῶνος οὐκ ἠκούσαμεν οὐδὲ οἱ ὀφθαλμοὶ ἡμῶν εἶδον θεὸν πλὴν σοῦ, καὶ τὰ ἔργα σου ἃ ποιήσεις τοῖς ὑπομένουσιν ἔλεον.
Hebrew (WLC) shown from Isaias 64:3
וּמֵעוֹלָ֥ם לֹא שָׁמְע֖וּ לֹ֣א הֶאֱזִ֑ינוּ עַ֣יִן לֹֽא רָאָ֗תָה אֱלֹהִים֙ זוּלָ֣תְךָ֔ יַעֲשֶׂ֖ה לִמְחַכֵּה לֽוֹ

Haydock's commentary

Thee. Never was deliverance more unexpected or miraculous. St. Paul quotes this passage, to shew the wisdom manifested in the incarnation, 1 Corinthians ii. 9. It is commonly applied to the glory of heaven.

From Haydock's Catholic Bible Commentary, 1859, in the transcription made by Todd Easton and kept online by John Paul Wohlschied at johnblood.gitlab.io/haydock.

The Fathers on this verse

St Irenaeus Against Heresies: Book V, Chapter XXXVI. Men shall be actually

3. John, therefore, did distinctly foresee the first “resurrection of the just,” and the inheritance in the kingdom of the earth; and what the prophets have prophesied concerning it harmonize [with his vision]. For the Lord also taught these things, when He promised that He would have the mixed cup new with His disciples in the kingdom. The apostle, too, has confessed that the creation shall be free from the bondage of corruption, [so as to pass] into the liberty of the sons of God. …

Clement of Alexandria The Stromata, or Miscellanies, Chapter IV. Faith the Foundation of All Knowledge

Should one say that Knowledge is founded on demonstration by a process of reasoning, let him hear that first principles are incapable of demonstration; for they are known neither by art nor sagacity. For the latter is conversant about objects that are susceptible of change, while the former is practical solely, and not theoretical. Hence it is thought that the first cause of the universe can be apprehended by faith alone. For all knowledge is capable of being taught; and what is capable of being taught is founded on what is known before. But the first cause of the universe was not previously known to the Greeks; neither, accordingly, to Thales, who came to the conclusion that water was the first cause; nor to the other natural philosophers who succeeded him, since it was Anaxagoras who was the first who assigned to Mind the supremacy over material things. …

Origen Origen De Principiis, Chapter VI

4. And now, as we find the apostle making mention of a spiritual body, let us inquire, to the best of our ability, what idea we are to form of such a thing. So far, then, as our understanding can grasp it, we consider a spiritual body to be of such a nature as ought to be inhabited not only by all holy and perfect souls, but also by all those creatures which will be liberated from the slavery of corruption. Respecting the body also, the apostle has said, “We have a house not made with hands, eternal in the heavens,” i.e., in the mansions of the blessed. And from this statement we may form a conjecture, how pure, how refined, and how glorious are the qualities of that body, if we compare it with those which, although they are celestial bodies, and of most brilliant splendour, were nevertheless made with hands, and are visible to our sight. …

St Hippolytus The Refutation of All Heresies, Chapter XIX

But swear, says Justinus, if you wish to know “what eye hath not seen, and ear hath not heard, and the things which have not entered into the heart;” that is, if you wish to know Him who is good above all, Him who is more exalted, (swear) that you will preserve the secrets (of the Justinian) discipline, as intended to be kept silent. For also our Father, on beholding the Good One, and on being initiated with Him, preserved the mysteries respecting which silence is enjoined, and sware, as it has been written, “The Lord sware, and will not repent.” Having, then, in this way set the seal to these tenets, he seeks to inveigle (his followers) with more legends, (which are detailed) through a greater number of books; and so he conducts (his readers) to the Good One, consummating the initiated (by admitting them into) the unspeakable Mysteries. …

St Hippolytus The Refutation of All Heresies, Chapter XXI

When Elohim had prepared and created the world as a result from joint pleasure, He wished to ascend up to the elevated parts of heaven, and to see that not anything of what pertained to the creation laboured under deficiency. And He took His Own angels with Him, for His nature was to mount aloft, leaving Edem below: for inasmuch as she was earth, she was not disposed to follow upward her spouse. Elohim, then, coming to the highest part of heaven above, and beholding a light superior to that which He Himself had created, exclaimed, “Open me the gates, that entering in I may acknowledge the Lord; for I considered Myself to be Lord.” A voice was returned to Him from the light, saying, “This is the gate of the Lord: through this the righteous enter in.” And immediately the gate was opened, and the Father, without the angels, entered, (advancing) towards the Good One, and beheld “what eye hat …

Pseudo-Hippolytus Appendix to the Works of Hippolytus. Containing Dubious and Spurious Pieces, Section XLIV

Then shall the King of kings make answer again, and say to them, Inasmuch as ye have done it unto one of the least of these my brethren, ye have done it unto me. Inasmuch as ye have received those of whom I have already spoken to you, and clothed them, and fed them, and gave them to drink, I mean the poor who are my members, ye have done it unto me. But come ye into the kingdom prepared for you from the foundation of the world; enjoy for ever and ever that which is given you by my Father in heaven, and the holy and quickening Spirit. And what mouth then will be able to tell out those blessings which eye hath not seen, nor ear heard, neither have entered into the heart of man, the things which God hath prepared for them that love Him?

St Augustine Book IX, Chapter X

23. As the day now approached on which she was to depart this life (which day Thou knewest, we did not), it fell out, Thou, as I believe, by Thy secret ways arranging it, that she and I stood alone, leaning in a certain window, from which the garden of the house we occupied at Ostia could be seen; at which place, removed from the crowd, we were resting ourselves for the voyage, after the fatigues of a long journey. We then were conversing alone very pleasantly; and, “forgetting those things which are behind, and reaching forth unto those things which are before,” we were seeking between ourselves in the presence of the Truth, which Thou art, of what nature the eternal life of the saints would be, which eye hath not seen, nor ear heard, neither hath entered into the heart of man. …

St Augustine Our Lord’s Sermon on the Mount, Chapter IV

11. Hence also the sevenfold operation of the Holy Ghost, of which Isaiah speaks, seems to me to correspond to these stages and sentences. But there is a difference of order: for there the enumeration begins with the more excellent, but here with the inferior. For there it begins with wisdom, and closes with the fear of God: but “the fear of the Lord is the beginning of wisdom.” And therefore, if we reckon as it were in a gradually ascending series, there the fear of God is first, piety second, knowledge third, fortitude fourth, counsel fifth, understanding sixth, wisdom seventh. The fear of God corresponds to the humble, of whom it is here said, “Blessed are the poor in spirit,” i.e. those not puffed up, not proud: to whom the apostle says, “Be not high-minded, but fear;” i.e. be not lifted up. …

St Augustine Lectures or Tractates on the Gospel According to St. John, Chapter VIII. 28-32

9. What, brethren, does He promise believers? “And ye shall know the truth.” Why so? Had they not come to such knowledge when the Lord was speaking? If they had not, how did they believe? They believed, not because they knew, but that they might come to know. For we believe in order that we may know, we do not know in order that we may believe. For what we shall yet know, neither eye hath seen, nor ear heard, nor hath it entered the heart of man. For what is faith, but believing what you see not? Faith then is to believe what you see not; truth, to see what you have believed, as He Himself saith in a certain place. The Lord then walked on earth, first of all, for the creation of faith. He was man, He was made in a low condition. He was seen by all, but not by all was He known. …

St Augustine Ten Homilies on the First Epistle of John, 1 John IV. 4-12

1. So is this world to all the faithful seeking their own country, as was the desert to the people Israel. They wandered indeed as yet, and were seeking their own country: but with God for their guide they could not wander astray. Their way was God’s bidding. For where they went about during forty years, the journey itself is made up of a very few stations, and is known to all. They were retarded because they were in training, not because they were forsaken. That therefore which God promiseth us is ineffable sweetness and a good, as the Scripture saith, and as ye have often heard by us rehearsed, which “eye hath not seen, nor ear heard, neither hath entered into the heart of man.” But by temporal labors we are exercised, and by temptations of this present life are trained. Howbeit, if ye would not die of thirst in this wilderness, drink charity. …

St Augustine Expositions on the Book of Psalms, Psalm XXXVI

4. “He hath meditated iniquity on his bed.” What said He, “On his bed?” ( ver. 4 ). “The ungodly hath said in himself, that he will sin:” what above he said, in himself, that here he said, “On his bed.” Our bed is our heart: there we suffer the tossing of an evil conscience; and there we rest when our conscience is good. Whoso loveth the bed of his heart, let him do some good therein. There is our bed, where the Lord Jesus Christ commands us to pray. “Enter into thy chamber, and shut thy door.” What is, “Shut thy door?” Expect not from God such things as are without, but such as are within; “and thy Father which seeth in secret, shall reward thee openly.” Who is he that shutteth not the door? He who asketh much from God such things, and in such wise directeth all his prayers, that he may receive the goods that are of this world. Thy door is open, the multitude seeth when thou prayest. …

St John Chrysostom An Exhortation to Theodore After His Fall, Letter I

13. Now these are things which will happen in that day: but the things which will follow, after these, what language can describe to us, the pleasure, the profit, the joy of being in the company of Christ? For when the soul has returned to the proper condition of nobility, and is able henceforth with much boldness to behold its Master it is impossible to say what great pleasure it derives therefrom, what great gain, rejoicing not only in the good things actually in hand, but in the persuasion that these things will never come to an end. All that gladness then cannot be described in words, nor grasped by the understanding: but in a dim kind of way, as one indicates great things by means of small ones, I will endeavour to make it manifest. …

10 more passages of the Fathers cite this verse. The Motif Searcher in the palace lists them all.