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1 Thessalonians 2:16

Prohibiting us to speak to the Gentiles, that they may be saved, to fill up their sins always: for the wrath of God is come upon them to the end.

Challoner: To fill up their sinsThat is, to fill up the measure of their sins, after which God's justice would punish them. For the wrath of God is come upon them to the end-- That is, to continue on them to the end.
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The verse in its languages

Vulgate (Clementine)
prohibentes nos gentibus loqui ut salvæ fiant, ut impleant peccata sua semper : pervenit enim ira Dei super illos usque in finem.
Greek New Testament (SBLGNT)
κωλυόντων ἡμᾶς τοῖς ἔθνεσιν λαλῆσαι ἵνα σωθῶσιν, εἰς τὸ ἀναπληρῶσαι αὐτῶν τὰς ἁμαρτίας πάντοτε. ἔφθασεν δὲ ἐπʼ αὐτοὺς ἡ ὀργὴ εἰς τέλος.

Haydock's commentary

To full up the measure of their sins, after which God's justice would punish them. (Witham)

The Jews filled up the measure of their iniquities by the opposition they every where manifested to the religion of Christ. The earliest Fathers of the Church testify that they dispersed people into every nation to blaspheme the name of Christ; and hence sprang the evil fame which Christians bore among the pagans. See the apologies of St. Justin Martyr, Tertullian, Origen, &c.

For the wrath of God is come upon them to the end. It seems a foretelling of their entire destruction, which happened not long after under Vespasian and Adrian. (Witham)

Where a note speaks of the Jewish people, the Church teaches that the Passion cannot be charged against all the Jews then living, nor against the Jews of today, and that all sinners were its authors (CCC 597, 598).

From Haydock's Catholic Bible Commentary, 1859, in the transcription made by Todd Easton and kept online by John Paul Wohlschied at johnblood.gitlab.io/haydock.

The Fathers on this verse

St John Chrysostom A Commentary on the Acts of the Apostles, Homily XXV on Acts xi. 19

“Now they which were scattered abroad upon the persecution,” etc. (Recapitulation.) Do you mark how even in the tribulation instead of falling to lamentations and tears, as we do, they give themselves up to a great and good work? “Travelled as far as Phenice, and Cyprus, and Antioch,” and there with more security preached the word. “And some of them, which were men of Cyprus and Cyrene,” etc. ( v. 20 .) And they did not say, “(What), we, Cyrenians and Cyprians, to attack this splendid and great city!” but trusting in the grace of God, they applied themselves to the work of teaching, nor did these (Gentiles) themselves think scorn to learn anything of them. Mark how by small means all is brought about: mark the preaching how it spreads: mark those in Jerusalem, having like care for all, holding the whole world as one house. “They heard that Samaria had received the word, and” ( ch. viii. …

St John Chrysostom A Commentary on the Acts of the Apostles, Homily XXXVII on Acts xvii. 1, 2, 3

(Recapitulation.) “Three sabbath-days,” it says, being the time when they had leisure from work, “he reasoned with them, opening out of the Scriptures” ( v. 2 ): for so used Christ also to do: as on many occasions we find Him reasoning from the Scriptures, and not on all occasions (urging men) by miracles. Because to this indeed they stood in a posture of hostility, calling them deceivers and jugglers; but he that persuades men by reasons from the Scriptures, is not liable to this imputation. And on many occasions we find (Paul) to have convinced men simply by force of teaching: and in Antioch “the whole city was gathered together” ( ch. xiii. 44 ): so great a thing is this also, for indeed this itself is no small miracle, nay, it is even a very great one. …

St John Chrysostom The Homilies of St. John Chrysostom on Philippians, Colossians, and Thessalonians, 1 Thessalonians 2:9-12

Ver. 14, 15, 16 . “For ye, brethren, became imitators of the Churches of God, which are in Judæa in Christ Jesus: for ye also suffered the same things of your own countrymen, even as they did of the Jews; who both killed the Lord Jesus and their own prophets, and drave out us, and please not God, and are contrary to all men; forbidding us to speak to the Gentiles that they may be saved; to fill up their sins alway: but the wrath is come upon them to the uttermost.”

St Cyril of Jerusalem On the Clause, And Shall Come in Glory to Judge the Quick and the Dead; Of Whose Kingdom There Shall Be No End

21. Thou seest how they all foretell the coming of the Lord. Thou seest how they know the voice of the sparrow . Let us know what sort of voice this is. For the Lord Himself shall descend from heaven with a shout, with the voice of the Archangel, and with the trump of God . The Archangel shall make proclamation and say to all, Arise to meet the Lord . And fearful will be that descent of our Master. David says, God shall manifestly come, even our God, and shall not keep silence; a fire shall burn before Him, and a fierce tempest round about Him , and the rest. The Son of Man shall come to the Father, according to the Scripture which was just now read, on the clouds of heaven , drawn by a stream of fire , which is to make trial of men. …

St Basil The Letters, To Amphilochius, bishop of Iconium

1. The interest which you have shewn in the affairs of the Isaurian Church is only what might have been expected from that zeal and propriety of conduct which so continually rouses my admiration of you. The most careless observer must at once perceive that it is in all respects more advantageous for care and anxiety to be divided among several bishops. This has not escaped your observation, and you have done well in noting, and in acquainting me with, the position of affairs. But it is not easy to find fit men. While, then, we are desirous of having the credit that comes of numbers, and cause God’s Church to be more effectively administered by more officers, let us be careful lest we unwittingly bring the word into contempt on account of the unsatisfactory character of the men who are called to office, and accustom the laity to indifference. …

The Fathers are given as they wrote. Where a passage lays the Passion on the Jewish people, the Church teaches that it cannot be charged against all the Jews then living, nor against the Jews of today, and that all sinners were its authors (CCC 597, 598).