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2 Timothy 3:1

Know also this, that, in the last days, shall come dangerous times.

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The verse in its languages

Vulgate (Clementine)
Hoc autem scito, quod in novissimis diebus instabunt tempora periculosa :
Greek New Testament (SBLGNT)
Τοῦτο δὲ γίνωσκε ὅτι ἐν ἐσχάταις ἡμέραις ἐνστήσονται καιροὶ χαλεποί·

Haydock's commentary

Know. Do not be troubled at the many evils, persecutions, and heresies, which rise up against the Church. There have ever existed such since the Church was first established, and such ever will exist. Did not Jannes and Mambres rise up against Moses? (Calmet) See 1 Timothy iv. 1.; 2 Peter iii. 3.; Jude 18.

That in the last days. It only signifies hereafter. And the advice St. Paul gives to Timothy, (ver. 5.) now these avoid; shews that some of those false teachers should come in St. Timothy's days. We may observe that few agree exactly in translating or expounding the sense of so many Greek or Latin words, which express the vices of such heretics; but the difference is so small, that it need not be taken notice of. (Witham)

From Haydock's Catholic Bible Commentary, 1859, in the transcription made by Todd Easton and kept online by John Paul Wohlschied at johnblood.gitlab.io/haydock.

The Fathers on this verse

St Augustine Lectures or Tractates on the Gospel According to St. John, Chapter XXI. 12-19

5. But first the Lord asks what He knew, and that not once, but a second and a third time, whether Peter loved Him; and just as often He has the same answer, that He is loved, while just as often He gives Peter the same charge to feed His sheep. To the threefold denial there is now appended a threefold confession, that his tongue may not yield a feebler service to love than to fear, and imminent death may not appear to have elicited more from the lips than present life. Let it be the office of love to feed the Lord’s flock, if it was the signal of fear to deny the Shepherd. Those who have this purpose in feeding the flock of Christ, that they may have them as their own, and not as Christ’s, are convicted of loving themselves, and not Christ, from the desire either of boasting, or wielding power, or acquiring gain, and not from the love of obeying, serving, and pleasing God. …

St John Chrysostom The Homilies of St. John Chrysostom on Timothy, Titus, and Philemon, 2 Timothy 3:1-7

2 Timothy iii. 1-7 “This know also, that in the last days perilous times shall come. For men shall be lovers of their own selves, covetous, boasters, proud, blasphemers, disobedient to parents, unthankful, unholy, Without natural affection, truce-breakers, false accusers, incontinent, fierce, despisers of those that are good, Traitors, heady, high-minded, lovers of pleasure more than lovers of God; Having a form of godliness, but denying the power thereof; from such turn away. For of this sort are they, which creep into houses, and lead captive silly women laden with sins, led away with divers lusts and pleasures, Ever learning, and never able to come to the knowledge of the truth.”

St John Chrysostom The Homilies of St. John Chrysostom on Timothy, Titus, and Philemon, 2 Timothy 3:1-4

2 Timothy iii. 1-4 “This know also, that in the last days perilous times shall come. For men shall be lovers of their own selves, covetous, boasters, proud, blasphemers, disobedient to parents, unthankful, unholy, without natural affection, truce-breakers, false accusers, incontinent, fierce, despisers of those that are good, Traitors, heady, high-minded, lovers of pleasures more than lovers of God.”